Granisetron hydrochloride is used as an antiemetic for nausea and vomiting caused by chemotherapy and radiation therapy.
Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist with good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy, and surgery can cause intestinal chromaffin cells to release 5-HT, which activates 5-HT3 receptors in the central or vagus nerve and causes a gag reflex. The mechanism of granisetron hydrochloride to control nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing the 5-HT3 receptors of the central chemoreceptor and peripheral vagus nerve endings. Granisetron hydrochloride has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.
|Appearance||White or almost white powder||Conforms|
|Loss on drying||≤0.5%||0.18%|
|Average particle size||100 micon:80%;100-120Micron:20%||Conforms|
|Impurity E (TLC)||≤0.5%||Conforms|
|Residual solvents||Methanol ≤0.3%|
Methylene dichloride ≤0.06%
|Related substances(HPLC)||Impurity A ≤0.5%|
Impurity B ≤0.5%
Impurity C ≤0.2%
Impurity D ≤0.1%
Any other impurity ≤0.1%
Total Impurity ≤1.0%
|Appearance:||White or almost white powder|
|Package details:||1kg/foil bag|
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