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Cocarboxylase, or thiamine pyrophosphate (TPP), is the active coenzyme form of vitamin B1 (thiamine). It is essential for carbohydrate metabolism, serving as a cofactor in key enzymatic reactions. TPP facilitates the decarboxylation of alpha-keto acids (e.g., pyruvate to acetyl-CoA in the Krebs cycle) and participates in transketolase reactions in the pentose phosphate pathway, aiding energy (ATP) production and sugar metabolism. It is critical for neurological function, as neurons depend on glucose metabolism. Deficiency impairs these processes, leading to disorders like beriberi or Wernicke-Korsakoff syndrome. Clinically, it is used to treat thiamine deficiency, often linked to alcoholism, malnutrition, or metabolic disorders.
Items | Specifications | Results |
Appearance(25℃) | White or off-white powder | Off-white powder |
Identification(IR) | IR spectrum should complies with the standard | Complies |
PH(10%,water) | Should be 1.0~1.7 | 1.5 |
Related substances | Thiamine monophosphoric acid ester hydrochloride(HPLC) ≤2.0% | Complies |
Thiamine hydrochloride(HPLC) ≤0.1% | 0.03% | |
Loss on drying(130℃) | Not more than 1.0% | 0.7% |
Chloride(on anhydrous substance) | 7.5%~7.9% | 7.8% |
Heavy metals(as Pb) | NMT 10ppm | Complies |
Assay(HPLC) | ≥98.5% | 99.1% |
Conclusion | The product conforms to the above specifications. | |
CAS:154-87-0
MF:C12H19N4O7P2S.Cl
Melting point :240～241℃
form:powder
color:White or off-white powder
Uses:
Cocarboxylase is the coenzyme form of thiamine (vitamin B1), known chemically as thiamine pyrophosphate (TPP). It plays a critical role in cellular metabolism, particularly in enzymatic reactions involving the decarboxylation of alpha-keto acids, such as pyruvate and alpha-ketoglutarate, in key metabolic pathways like the Krebs cycle. Here's a detailed breakdown:
Structure: TPP consists of thiamine (vitamin B1) with two phosphate groups added, making it the active coenzyme form.
Function:
Decarboxylation Reactions: Facilitates the removal of carboxyl groups (-COOH) from molecules, such as converting pyruvate to acetyl-CoA (critical for entry into the Krebs cycle) and alpha-ketoglutarate to succinyl-CoA.
Aldehyde Transfer: Acts as a cofactor in transketolase reactions in the pentose phosphate pathway, aiding in sugar metabolism.
Metabolic Importance:
Essential for energy production (ATP synthesis) via carbohydrate metabolism.
Supports nervous system function, as neurons rely heavily on glucose metabolism.
Deficiency Implications:
Thiamine deficiency leads to impaired TPP production, causing disorders like beriberi (characterized by nerve, heart, and muscle issues) and Wernicke-Korsakoff syndrome (associated with alcoholism).
Medical Use:
Administered clinically to treat thiamine deficiency or conditions like metabolic disorders, alcoholism, or malnutrition.
The term "cocarboxylase" originates from its role as a coenzyme for carboxylase enzymes, though it is primarily involved in decarboxylation (removing CO₂) rather than carboxylation (adding CO₂). This naming reflects early biochemical nomenclature.
In summary, cocarboxylase (TPP) is vital for converting food into usable energy and maintaining neurological health, underscoring the importance of adequate thiamine intake through diet or supplements.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Cocarboxylase with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Cocarboxylase.
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