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Methoxyl-PEG₁₆-alcohol (abbreviated mPEG₁₆-OH) is a monofunctional polyethylene glycol (PEG) derivative with the structure:
CH₃O-(CH₂CH₂O)₁₆-H.
Structure:
Methoxy terminus (–OCH₃): Chemically inert end.
Hydroxyl terminus (–OH): Reactive end for conjugation.
16 ethylene oxide (EO) units: Defines chain length (PEG "16-mer").
Formula: C₃₃H₆₈O₁₇ (MW ≈ 724 g/mol).
Properties:
Water-soluble, non-ionic polymer.
Low toxicity, biocompatible.
Applications:
Bioconjugation: Attaching to proteins/drugs via –OH group to enhance solubility, stability, and circulation time ("PEGylation").
Biomedical research: Drug delivery, hydrogels, surface modification.
The chemical name Methoxyl-PEG₁₆-alcohol (also written as mPEG₁₆-OH or CH₃O-PEG₁₆-OH) refers to a specific monodisperse or polydisperse polyethylene glycol (PEG) derivative with the following structure:
CH₃O-(CH₂CH₂O)₁₆-H
Terminal Groups:
Methoxyl (CH₃O-): One end is capped with a methyl ether group.
Alcohol (-OH): The other end has a hydroxyl group.
PEG Chain Length:
"PEG₁₆" indicates 16 repeating ethylene oxide units (–CH₂CH₂O–).
Total atoms in the chain: 16 × (C₂H₄O).
Molecular Formula:
C₃₃H₆₈O₁₇
Calculated as: CH₃O- (C₂H₄O)₁₆-H → C₃₃H₆₈O₁₇
Exact mass: ~ 724.44 g/mol (monodisperse).
Structure:
CH₃-O-(CH₂-CH₂-O)₁₆-H
"PEG₁₆" vs. "16-mer":
"PEG₁₆" explicitly means 16 ethylene oxide (EO) units, not 16 total atoms.
Polydispersity:
Commercial products may have a range of chain lengths (e.g., PEG₁₄–PEG₁₈), characterized by a polydispersity index (PDI). High-purity grades offer near-monodisperse chains.
Synonyms:
mPEG₁₆-OH
Methyl-PEG₁₆-alcohol
α-Methoxy-ω-hydroxyhexaethoxy glycol
Bioconjugation:
Functionalizing proteins, peptides, or nanoparticles via the reactive –OH group (e.g., creating PEGylated drugs).
Drug Delivery:
Improving solubility and pharmacokinetics of therapeutics.
Crosslinking Agent:
Used in hydrogels or polymer networks (the –OH group reacts with isocyanates, epoxides, etc.).
Surface Modification:
Grafting onto materials to create non-fouling (anti-protein adsorption) surfaces.
Methoxyl-PEG₁₆-alcohol is not a surfactant with a C₁₆ alkyl chain.
Instead, it is a hydrophilic PEG polymer with a defined length (16 EO units), used primarily in biomedical applications.
For industrial uses (e.g., surfactants), compounds like C₁₆H₃₃-(OCH₂CH₂)ₙ-OCH₃ would be labeled as "Methoxy PEG-X Hexadecyl Ether" (where X = EO number).
Let me know if you need synthesis details or specific application protocols!
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