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Introduction of Spermine is a naturally occurring polyamine (C₁₀H₂₆N₄) with four amine groups, synthesized from spermidine. It plays critical roles in cellular processes: stabilizing DNA/RNA, regulating gene expression, promoting cell growth, and modulating apoptosis. Spermine also acts as an antioxidant, neutralizing free radicals, and induces autophagy, supporting cellular health and longevity. Found in foods like meat, soy, and aged cheeses, it is produced endogenously from ornithine. Research links it to anti-aging, neuroprotection, and cardiovascular benefits, though its role in cancer is complex—balancing tumor suppression and proliferation. Generally safe in dietary amounts, excessive supplementation may pose risks. Its cationic nature underpins interactions with biomolecules and therapeutic potential.
Description of Spermine from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Spermine | |
Product Name | Spermine |
CAS NO. | 71-44-3 |
Apperance | Colorless solid |
Assay | 98.2% |
Pacakge | 1kg/Foil Bag, 25kg/ Box/carton |
MOQ | 1kg |
Storage | |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of Spermine CAS 71-44-3
Items | Specifications | Results |
Appearance | Colorless solid | |
Identification | MS spectrum should conform to the structure | Conforms |
`H NMR spectrum should conform to the structure | Conforms | |
Purity | ≥98.0% | 98.2% |
Largesst single impurity | ≤1.0% | 0.54% |
Nickel | ≤0.5 ppm | 0.10 ppm |
Assay | ≥97.0% | 98.7% |
Storage | Keep tightly stoppered in the dark at 2~8℃ | |
Conclusion | Complies with the In-house specification. | |
Introduction of Spermine is a naturally occurring polyamine (C₁₀H₂₆N₄) with four amine groups, synthesized from spermidine. It plays critical roles in cellular processes: stabilizing DNA/RNA, regulating gene expression, promoting cell growth, and modulating apoptosis. Spermine also acts as an antioxidant, neutralizing free radicals, and induces autophagy, supporting cellular health and longevity. Found in foods like meat, soy, and aged cheeses, it is produced endogenously from ornithine. Research links it to anti-aging, neuroprotection, and cardiovascular benefits, though its role in cancer is complex—balancing tumor suppression and proliferation. Generally safe in dietary amounts, excessive supplementation may pose risks. Its cationic nature underpins interactions with biomolecules and therapeutic potential.
Application of Spermine: Chemical Overview
IUPAC Name: *N,N'-Bis(3-aminopropyl)butane-1,4-diamine*
Molecular Formula: C₁₀H₂₆N₄
Structure: A linear polyamine with four amine groups connected by three methylene chains:
NH₂-(CH₂)₃-NH-(CH₂)₄-NH-(CH₂)₃-NH₂
SMILES Notation: NCCCNCCCCNCCCN
Spermine is biosynthesized in eukaryotic cells through the polyamine pathway:
1. Precursor: Derived from spermidine (a triamine) via enzymatic addition of an aminopropyl group.
2. Enzyme: Spermine synthase catalyzes the transfer of the aminopropyl group from decarboxylated S-adenosylmethionine (dcSAM) to spermidine.
Appearance: White crystalline solid.
Solubility: Highly soluble in water (due to polar amine groups).
Molecular Weight: 202.34 g/mol.
Hygroscopic: Absorbs moisture from the air.
pKa Values: ~8–11 (basic due to four amine groups).
Strong Base: Protonates in physiological conditions, carrying a positive charge at neutral pH.
Chelation: Binds metal ions (e.g., Mg²⁺, Ca²⁺) via its amine groups.
Reactivity:
Reacts with acids to form salts (e.g., spermine tetrahydrochloride).
Oxidized by amine oxidases to produce reactive oxygen species (ROS).
Nucleic Acid Stabilization: Electrostatic binding to DNA/RNA (via positive charge) stabilizes structure and regulates gene expression.
Cell Proliferation: Essential for growth, differentiation, and tissue repair.
Apoptosis Regulation: Modulates programmed cell death pathways.
Antioxidant: Scavenges free radicals, protecting cells from oxidative damage.
Research: Studied for roles in aging, cancer, and neurodegenerative diseases (e.g., Alzheimer’s).
Biotechnology: Used to condense DNA in gene delivery systems (e.g., transfection reagents).
Supplements: Marketed for potential anti-aging benefits (limited clinical evidence).
Structure: Spermine has 4 amine groups vs. spermidine’s 3.
Function: Both stabilize nucleic acids, but spermine has stronger DNA-binding capacity and antioxidant activity.
Natural Occurrence: Safe at physiological levels (found in foods like meat, soy, and aged cheese).
Toxicity: High doses (e.g., supplements) may cause nausea, headaches, or hypotension.
Handling: Use gloves in lab settings (irritant in concentrated forms).
Oxidation by Amine Oxidases:
Spermine → Spermidine + H₂O₂ (hydrogen peroxide).
This reaction links spermine metabolism to cellular redox signaling.
Spermine is a critical polyamine with a unique chemical structure enabling roles in DNA stabilization, cell growth, and oxidative stress defense. Its strong positive charge and amine reactivity underpin both biological functions and research applications. While naturally safe, concentrated forms require cautious handling.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Spermine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Spermine.
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