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Pyrrolidinyl diaminopyrimidine oxide is used as an organic chemical raw material.
Pyrrolidinyl diaminopyrimidine oxide (CAS 55921-65-8; Kopyrrol) is the pyrrolidine analogue of minoxidil — a water-soluble 2,4-diamino-6-(1-pyrrolidinyl)pyrimidine N-oxide. It shares minoxidil's pharmacophore, acting as a mild topical K-ATP channel opener to improve perifollicular circulation and prolong anagen.
Uses: leave-on anti-hair-loss serums, ampoules, tonics and foams (0.5–2%), rinse-off shampoos/masks, blended with aminexil, caffeine, niacinamide, zinc PCA or peptides; not a drug.
Selling points: freely water-soluble → alcohol-free, PG-light, no crystallisation; minoxidil-like story without drug status; milder profile, no systemic hypotension; non-hormonal; easy aqueous processing; multi-pathway synergy; listed in China's existing ingredient inventory.
Caveats: evidence weaker than minoxidil 5%; pyrrolidine ring carries nitrosamine risk — control free pyrrolidine and avoid nitrites; possible scalp irritation and unwanted facial hair; avoid broken skin, pregnancy, children; eye area ~0.5%. Distinct from Aminexil (CAS 74638-76-9).
| Items | Specification | Result |
| Assay | ≥99% | 99.53% |
| Apperance | White or off-white crystal | Complies |
| Moisture content | ≤1.0% | 0.42% |
| Heavy metal | ≤20ppm | Complies |
| Product parameters | |
| Cas number: | 55921-65-8 |
| Appearance: | White to off white crystal |
| Purity: | 99%min |
| MOQ: | 1kg |
| Price: | Negotiable |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
Uses:
Pyrrolidinyl diaminopyrimidine oxide (INCI; CAS 55921-65-8, C₈H₁₃N₅O, MW 195.22; trade name Kopyrrol, is the pyrrolidine analogue of minoxidil: 2,4-diamino-6-(1-pyrrolidinyl)pyrimidine 3-oxide. It is typically made by nucleophilic substitution of pyrrolidine onto 2,6-diamino-4-chloropyrimidine N-oxide, giving a white to off-white crystalline powder, m.p. ~276–278 °C (dec.), freely soluble in water, essentially odourless, and listed in INCI/Japan/Korea inventories with the functions hair conditioning and hair waving/straightening.
Mechanism (as claimed / inferred): as a 2,4-diamino-pyrimidine N-oxide bearing a tertiary amine at C6, it shares minoxidil's pharmacophore and is regarded as a mild topical K-ATP channel opener / vasodilator that improves perifollicular microcirculation and prolongs anagen; like its congeners it is also attributed with anti-perifollicular-fibrosis (lysyl-hydroxylase down-regulation) and weak 5α-reductase-inhibiting activity. Note: the LH-inhibition data are robust for minoxidil and for 2,4-diaminopyrimidine-3-oxide (aminexil/Kopexil); for the pyrrolidine analogue most evidence is supplier-level and structure-based rather than head-to-head clinical.
| Name | CAS | C6 substituent | Status |
|---|---|---|---|
| Minoxidil | 38304-91-5 | piperidine | Drug (OTC/Rx), 2–5% |
| Diaminopyrimidine oxide (Aminexil/Kopexil) | 74638-76-9 | H (none) | Cosmetic; China restricted hair-use max 1.5% |
| Pyrrolidinyl diaminopyrimidine oxide (Kopyrrol) | 55921-65-8 | pyrrolidine | Cosmetic raw material, highly water-soluble |
Uses
Leave-on anti-hair-loss scalp products: serums, ampoules/monodose vials, lotions, tonics, sprays, foams — primary use, typically 0.5–2% (up to ~4% in head leave-on per Chinese market usage information).
Rinse-off hair care: anti-fall shampoos, conditioners and masks (lower dose, mainly claim support and conditioning).
Combination formulas: paired with aminexil/diaminopyrimidine oxide ("circulation + anti-fibrosis" dual path), caffeine, niacinamide, arginine, zinc PCA, procyanidin B2, Redensyl/Anagain-type botanicals, peptides, and ketoconazole or climbazole in dandruff-plus-hair-fall SKUs.
Scalp-microbiome / soothing lines: oil-control and sebum-balancing treatments where alcohol-free, low-irritancy vehicles are required.
Eyebrow/eyelash-adjacent serums — only at low levels and with eye-area limits observed (0.5% leave-on per Chinese usage info).
Pet grooming: dog/cat coat-thinning and shedding shampoos (off-label, vendor-dependent).
Not a drug: not approved as a pharmaceutical in the US or EU; in China, anti-hair-loss efficacy claims still require special-cosmetic registration despite the ingredient being on the existing-ingredient list.
Selling points
| Selling point | Practical meaning |
|---|---|
| High water solubility | Unlike minoxidil and aminexil, it dissolves in water without 30–50% propylene glycol or 40% ethanol → alcohol-free, PG-light, low-sting formulas for sensitive scalps; no crystallisation/haze on standing |
| "Minoxidil-like" story without drug status | Same N-oxide pharmacophore narrative for marketing, but sold as a cosmetic ingredient — no prescription, no drug monograph, easier SKU development |
| Milder safety profile than minoxidil | No clinically relevant systemic hypotension at cosmetic use levels; no mandatory shedding phase widely reported; suitable for long-term maintenance and for users who refuse drugs |
| Non-hormonal, gender-neutral positioning | Appeals to women, post-partum/reactional shedding and early-stage thinning where minoxidil feels "too medical" |
| Good compatibility & stability | Crystalline solid, easy to weigh/dissolve in the aqueous phase at ambient-to-warm temperature; compatible with cationic polymers, surfactants and most other hair actives |
| Synergy anchor | Combines mechanistically with aminexil (fibrosis), caffeine (phosphodiesterase/circulation) and DHT-targeting botanicals → multi-pathway claims and higher perceived efficacy |
| Cleaner label than alcohol-heavy minoxidil tinctures | Supports "no ethanol / no minoxidil / no hormones" claims; better odour and aesthetics in leave-on serums |
| Established inventory status | Listed in China's Inventory of Existing Cosmetic Ingredients (No. 01326) with published market usage levels (whole-body leave-on 1%, head leave-on 4%, eye area 0.5%), easing safety-assessment filing |
Caveats (must be stated alongside)
Evidence gap vs minoxidil 5%: far fewer independent, peer-reviewed RCTs; effect size is modest and best positioned for reduced shedding/maintenance rather than regrowth of advanced androgenetic alopecia. Avoid over-claiming.
Nitrosamine risk is the real compliance issue: the pyrrolidine moiety is a secondary amine capable of forming N-nitrosopyrrolidine (a potent carcinogen). Procure with a certificate for free pyrrolidine residue, nitrosamine limits, and absence of nitrosating agents; do not co-formulate with nitrite-containing raw materials.
Residual starting material: control 2,6-diamino-4-chloropyrimidine N-oxide and free pyrrolidine in the specification; request a full impurity profile and heavy-metals/microbiology COA.
Irritation & hypertrichosis: scalp itching, erythema and contact dermatitis can occur; facial application or runoff can cause unwanted hair growth (forehead, temples) — instruct careful application and hand washing.
Contra-indications/precautions: avoid on broken, inflamed or sunburned scalp; avoid during pregnancy and lactation and in children (minoxidil-class precaution); discontinue if palpitations, dizziness or oedema occur.
Eye area limited to ~0.5% leave-on (per Chinese published usage information); there is no CIR/SCCS opinion published for this INCI — justify your use level with a full safety assessment and local rules.
Regulatory divergence matters: diaminopyrimidine oxide (Aminexil) is capped at 1.5% in hair products in China; Kopyrrol is a different INCI with different status. Mixing up the names on labels/registrations is a common compliance error — always declare by exact INCI and CAS.
Storage: protect from light and moisture; typical use levels 0.5–2%; verify target-market rules before launch.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Pyrrolidinyl Diaminopyrimidine Oxide with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Pyrrolidinyl Diaminopyrimidine Oxide.
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