Name: China Supplier High Quality Best Price Lactulose CAS 4618-18-2 for Food Additives
Brand: Wuhan Fortuna Chemical Co., Ltd.

In simple terms, Lactulose is a type of synthetic sugar used as a medication to treat constipation and a serious liver condition called hepatic encephalopathy.

It is not absorbed by the body. Instead, it works by drawing water into the colon and being broken down by bacteria in the gut, which leads to its effects.

How Does It Work?

Lactulose works through two primary mechanisms, depending on why it's being used:

1. For Constipation (as an Osmotic Laxative):

Osmotic Action: Lactulose is a "non-absorbable disaccharide," meaning your small intestine cannot digest or absorb it. When it reaches the colon, it draws water from the body into the colon through a process called osmosis.

Result: This water softens the stool, increases its volume, and stimulates the bowel muscles to contract, making it easier to pass. This process typically takes 2-3 days to work for constipation.

2. For Hepatic Encephalopathy (as a Ammonia-Lowering Agent):

Acidification of the Colon: In the colon, bacteria break down (ferment) lactulose into acids like lactic acid and acetic acid.

Trapping Ammonia: This acidic environment converts a harmful substance called ammonia (NH₃), which is produced by the body and normally processed by the liver, into ammonium ions (NH₄⁺).

Excretion: Ammonium ions are not easily absorbed into the bloodstream. Instead, they are trapped in the colon and expelled from the body through the stool.

Result: By reducing the amount of ammonia in the blood (a key trigger for brain fog and confusion in liver failure), lactulose helps improve mental function in patients with hepatic encephalopathy.

What is it Used For? (Medical Uses)

Treatment of Constipation: It is a common and effective first-line treatment for chronic constipation.
Treatment and Prevention of Hepatic Encephalopathy: This is a crucial use for patients with severe liver disease (like cirrhosis) who experience brain function changes due to toxin buildup.
Other Uses: Sometimes used in certain medical procedures to prepare the bowel.

Important Considerations

Form: It is a liquid syrup, usually clear and colorless or pale yellow. It has a sweet taste.

Brand Names: Common brand names include Duphalac, Generlac, and Kristalose (a crystallized powder form that is mixed with water).

Available By: It is a prescription medication in most countries, though it may be available over-the-counter in some regions.

Side Effects

The most common side effects are related to its mechanism of action and usually occur at the start of treatment. They often decrease as your body adjusts.

Very Common: Bloating, gas (flatulence), stomach cramps or discomfort.

Common: Nausea, vomiting, diarrhea.

Important: Diarrhea can be serious as it can lead to dehydration and electrolyte imbalances. If you experience severe diarrhea or abdominal pain, you should contact your doctor.

Precautions and Warnings

Other Medicines: Lactulose can affect how other medications are absorbed. It's important to take other drugs at least 2 hours before or after taking lactulose.

Medical Conditions: Inform your doctor if you have:

Diabetes (lactulose contains sugars, which can affect blood glucose).
Galactosemia (a rare genetic disorder).
Need for a low-lactose diet.

Dosage: It is crucial to follow the dosage instructions provided by your doctor or pharmacist, especially for hepatic encephalopathy, where the dose is adjusted to achieve 2-3 soft bowel movements per day.

Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or a qualified healthcare provider for any questions you may have regarding a medical condition or treatment.