Name: China Manufacturer High Quality Wholesale Price D-CYSTEINE HYDROCHLORIDE CAS 207121-46-8_copy20250909_copy20250909
Brand: Wuhan Fortuna Chemical Co., Ltd.

D-Cysteine Hydrochloride is the hydrochloride salt form of D-Cysteine, which is the D-enantiomer of the amino acid cysteine. Unlike the common, naturally occurring L-Cysteine, D-Cysteine is not used in protein synthesis by most living organisms and is relatively rare. Its primary significance lies in specific industrial, research, and biochemical applications.

Key Characteristics

Chemical Name: (R)-2-Amino-3-sulfanylpropanoic acid hydrochloride

CAS Number: 32443-99-5

Molecular Formula: C₃H₇NO₂S • HCl

Appearance: Typically a white crystalline powder.

Key Feature: It is the non-natural, mirror-image (stereoisomer) form of the proteinogenic amino acid L-Cysteine.

The Significance of the "D-" Prefix

The "D" and "L" nomenclature refers to the molecule's chirality, or handedness.

L-Cysteine: This is the form found in nature and incorporated into proteins in all living organisms. It is biologically active and plays crucial roles in protein structure (forming disulfide bonds), antioxidant defense (as a precursor to glutathione), and detoxification.

D-Cysteine: This form is not recognized by the enzymes and ribosomal machinery in most organisms and is therefore not used to build proteins. Its biological activity is distinct and often inhibitory.

Primary Applications and Uses

The unique properties of D-Cysteine hydrochloride lead to several specialized uses:

Biochemical Research:

Enzyme Studies: Used to probe the stereospecificity of enzymes. If an enzyme acts on L-cysteine, scientists can use D-cysteine to confirm that the reaction is specific to the "left-handed" form.
Inhibitor: It can act as an inhibitor for certain enzymes that process L-cysteine, helping to study their function and mechanism.

Preparation of Other Chemicals:

It serves as a chiral building block (a starting material with a specific handedness) in organic synthesis for creating more complex molecules, particularly in pharmaceutical research.

Potential Medical Applications (Research Stage):

Nephroprotective Agent: Promising research has shown that a specific enzyme (D-amino acid oxidase) in the kidneys can convert D-cysteine into a powerful hydrogen sulfide (H₂S) precursor. H₂S is a gasotransmitter with protective effects, suggesting D-cysteine could potentially be used to treat acute kidney injury. This is a key area of distinction from L-cysteine.
Antioxidant Properties: Like its L-form, it can still act as a direct antioxidant due to its thiol (-SH) group.

Food and Feed Industry (Limited):

While L-cysteine hydrochloride is widely used as a dough conditioner and flavor enhancer, D-cysteine is not used for this purpose as it is not metabolized in the same way.

Comparison to L-Cysteine Hydrochloride

Feature	D-Cysteine Hydrochloride	L-Cysteine Hydrochloride
Chirality	D-enantiomer (non-natural form)	L-enantiomer (natural form)
Protein Synthesis	Not incorporated	Incorporated into proteins
Primary Use	Research, chiral synthesis, potential therapeutics	Food additive (dough conditioner), dietary supplement, pharmaceutical ingredient
Biological Activity	Often inhibitory; converted to H₂S in kidneys via a specific pathway	Metabolic precursor to glutathione, taurine; used in protein synthesis

Summary

In essence, D-Cysteine Hydrochloride is a non-proteinogenic amino acid salt valued primarily for its role in scientific research as a stereospecific probe and inhibitor. Its emerging potential lies in medicine, where its unique metabolism in the kidneys could be harnessed for therapeutic benefit, distinguishing it fundamentally from its common L-form counterpart.