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Tetrabutylammonium Chloride Hydrate
Tetrabutylammonium chloride hydrate (TBAC hydrate) is a quaternary ammonium salt (C₁₆H₃₆ClN·xH₂O) — a white crystalline solid highly soluble in water and organic solvents.
Uses
Phase transfer catalyst in organic synthesis (alkylation, oxidation, coupling reactions)
Ion-pairing reagent in HPLC chromatography
Curing accelerator for epoxy resins and coatings
Phase change material for thermal energy storage
Gas separation enhancer in hydrate-based processes
Selling Points
Versatile — serves multiple industries (pharma, polymers, energy, oilfield)
High catalytic efficiency — enables milder conditions and higher yields
Green chemistry-aligned — recognized as a greener alternative
Cost-effective — inexpensive to produce, available in bulk
Easy to handle — excellent solubility and low melting point (41–44 °C)
In short, TBAC hydrate is a multi-functional, economically viable chemical with strong demand across diverse industrial applications.
Specifications of Tetrabutyl ammonium chloride hydrate CAS 37451-68-6 COA:
Items | Specifications | Results |
Appearance | White or yellow ceraceous solid | Complies |
Assay(%) | ≥95.0 | 97.83 |
Water(%) | ≤5.00 | 2.63 |
Conclusion | The product conforms to the above specifications. | |
Product Name:Tetrabutyl ammonium chloride hydrate
CAS:37451-68-6
MF:C16H38ClNO
Melting point :41-44 °C(lit.)
form:powder
color:White or yellow ceraceous
Uses:
| Property | Detail |
|---|---|
| CAS Number | 37451-68-6 (hydrate) / 1112-67-0 (anhydrous) |
| Molecular Weight | 277.92 g/mol (anhydrous) / 295.94 g/mol (monohydrate) |
| Appearance | White to off-white crystalline solid |
| Melting Point | 41–44 °C (hydrate) / 83–86 °C (anhydrous) |
| Solubility | Highly soluble in water, ethanol, chloroform, acetone |
| Key Trait | Hygroscopic (absorbs moisture from air) |
Primary Uses & Applications
Phase Transfer Catalyst (Core Application)
This is the most important and widely used function of TBAC hydrate. As a phase transfer catalyst (PTC), it enables reactions between substances that are normally immiscible (e.g., aqueous and organic phases) by shuttling reactants across phase boundaries. It is used in:
Halogen exchange reactions
N-alkylation reactions
Oxidation-reduction reactions
Dichlorocarbene generation
Michael additions
Heck-type cross-coupling reactions
Synthesis of 2-amino-4H-chromene derivatives
Esterification reactions (e.g., carboxylic acids with dimethyl carbonate)
Ion-Pair Chromatography Reagent
TBAC hydrate serves as an ion-pairing agent in high-performance liquid chromatography (HPLC), particularly for the separation and analysis of polar and acidic compounds. It improves peak shape and resolution.
Polymer & Coatings Industry
Used as a curing accelerator for epoxy resins and powder coatings, promoting cross-linking reactions during polymerization.
Thermal Energy Storage (Phase Change Material)
TBAC hydrate forms ionic semiclathrate hydrates — crystalline structures where water molecules create cages encapsulating TBAC ions. With an equilibrium temperature of ~15.1 °C and a dissociation enthalpy of 156 kJ/mol, it is used as a phase change material (PCM) in refrigeration and thermal energy storage systems.
Gas Separation
Research shows TBAC hydrate solutions can enhance gas hydrate formation for separation processes, such as coalbed methane (gas) separation, with significant improvements in gas consumption and growth rates.
Chloride Ion Source
In organic synthesis, TBAC hydrate acts as a chloride ion donor in radical-mediated C–H chlorination and other chlorination reactions.
Other Industrial Uses
Surfactant in detergents and emulsifiers
Corrosion inhibitor in metalworking fluids
Antimicrobial agent (bactericide/fungicide) in industrial settings
Oilfield chemical (clay swelling inhibitor, flooding agent)
Key Selling Points
If you are marketing or evaluating this product, here are the strongest selling points:
Versatility
TBAC hydrate is a true multi-functional chemical — it serves as a catalyst, chromatography reagent, curing agent, phase change material, and surfactant all in one compound. This makes it attractive across pharmaceutical, analytical, polymer, energy, and oilfield industries.
High Catalytic Efficiency
As a phase transfer catalyst, it enables reactions to proceed under milder conditions (lower temperatures, ambient pressure) with higher yields and faster reaction rates compared to uncatalyzed processes. This translates directly to cost savings in manufacturing.
Green Chemistry Alignment
Major suppliers like Sigma-Aldrich/Merck classify TBAC as a "Greener Alternative Product" aligned with the 12 Principles of Green Chemistry, specifically for its enhanced catalytic efficiency. It can also be used with phosphorus pentoxide for greener deoxychlorination processes.
Excellent Solubility Profile
Its high solubility in both water (20 mg/mL) and common organic solvents (ethanol, acetone, chloroform) makes it easy to handle and incorporate into diverse reaction systems without complex dissolution steps.
Low Melting Point (Hydrate Form)
The hydrate form's low melting point (41–44 °C) makes it easy to melt and process for applications like phase change thermal storage, without requiring high energy input.
Cost-Effectiveness
TBAC hydrate is relatively inexpensive to produce (synthesized from tetrabutylammonium hydroxide + hydrochloric acid) and is available in bulk from multiple global suppliers at competitive prices, making it economically viable for large-scale industrial use.
Established Track Record
It has been extensively cited in peer-reviewed literature across organic synthesis, drug discovery, and materials science, giving it strong credibility and reliability as a reagent.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Tetrabutyl ammonium chloride hydrate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Tetrabutyl ammonium chloride hydrate.
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