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3-Bromo-5-fluoro-2-methoxypyridine (corrected from "pyrdine") is a halogenated pyridine derivative with a bromine atom at position 3, fluorine at position 5, and a methoxy group (-OCH₃) at position 2. Its molecular formula is C₆H₅BrFNO (MW: ~220.01 g/mol). This compound serves as a key intermediate in pharmaceutical and agrochemical synthesis, particularly for drug candidates (e.g., kinase inhibitors) due to its reactivity in cross-coupling reactions (e.g., Suzuki-Miyaura). It is synthesized via halogenation and methoxylation of pyridine precursors. Handle with care—irritant risks from bromine/fluorine. Valued for its versatile substituents enabling targeted molecular modifications in organic chemistry.
3-Bromo-5-fluoro-2-methoxypyridine (corrected from "pyrdine") is a substituted pyridine derivative with the following structure:
Core: Pyridine ring (a 6-membered aromatic ring with one nitrogen atom).
Substituents:
Bromine (Br) at position 3 (meta to the nitrogen).
Fluorine (F) at position 5 (para to the nitrogen).
Methoxy (-OCH₃) at position 2 (ortho to the nitrogen).
Molecular Formula: C₆H₅BrFNO.
Molecular Weight: ~220.01 g/mol.
Appearance: Likely a white to off-white crystalline solid.
Applications:
Pharmaceutical Intermediate: Used in drug discovery, particularly in synthesizing bioactive molecules (e.g., kinase inhibitors).
Agrochemicals: May act as a building block for pesticides or herbicides.
Material Science: Potential use in ligands for catalysis.
Typically prepared via:
Halogenation (bromination/fluorination) of a pre-functionalized pyridine.
Methoxy group introduction via nucleophilic substitution (e.g., using methylating agents like CH₃I).
May be irritant (due to bromine/fluorine).
Handle with gloves/eye protection in a fume hood.
This compound’s halogen and methoxy groups enhance reactivity for cross-coupling reactions (e.g., Suzuki-Miyaura), making it valuable in organic synthesis.
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