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Propinox Hydrochloride is the hydrochloride salt of an obsolete quaternary ammonium anticholinergic drug.
Structure: Quaternary ammonium compound with a cyclopropylamino group and phenylacetate ester.
Formula: C₂₃H₃₀ClNO₃·HCl (or C₂₃H₃₁Cl₂NO₃).
Mechanism: Blocks muscarinic acetylcholine receptors, inhibiting nerve signals to smooth muscles/glands.
Historical Use:
Treated peptic ulcers, intestinal spasms, and hyperhidrosis (excessive sweating) in the mid-20th century.
Status: Discontinued due to severe anticholinergic side effects (e.g., dry mouth, blurred vision, urinary retention) and the rise of safer alternatives (e.g., H₂-blockers like cimetidine).
Propinox Hydrochloride is the hydrochloride salt of an obsolete anticholinergic drug. Here's its chemical profile:
Chemical Name:
2-Cyclopropylamino-1-phenyl-1-ethoxyacetate methyl bromide hydrochloride
Or: (2-Cyclopropylamino-1-phenylethyl) methylphenylacetate hydrochloride
Simplified: Quaternary ammonium anticholinergic agent.
Molecular Formula:
C₂₃H₃₀ClNO₃·HCl (as hydrochloride salt).
Structure Features:
Quaternary ammonium center (positively charged nitrogen).
Phenylacetate ester group.
Cyclopropylamino substituent.
Hydrochloride salt (improves solubility/stability).
Pharmacological Class:
Anticholinergic / Antimuscarinic agent (blocks acetylcholine receptors).
Historical Medical Uses:
Treatment of peptic ulcers, gastrointestinal spasms, and excessive sweating (now obsolete due to side effects).
Mechanism:
Inhibits smooth muscle contraction and glandular secretions by antagonizing muscarinic receptors.
Status:
No longer clinically used (replaced by safer drugs like Pirenzepine or H₂ receptor antagonists).
| Drug | Key Structural Difference |
|---|---|
| Propinox | Cyclopropylamino group |
| Propantheline | Isopropylamino group (broader use) |
High risk of anticholinergic side effects (dry mouth, blurred vision, tachycardia, constipation). Discontinued due to poor risk-benefit profile.
For synthesis or detailed pharmacology data, consult historical literature.
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