Name: Chemical Manufacturer Supply High Quality Best Price RU58841 CAS 154992-24-2 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Detailed Description

Specifications of RU58841 CAS 154992-24-2 COA:

Items	Specifications	Results
Appearance	White to off-white powder	Conforms
Identification	¹HNMR conforms to structure	Conforms
Residue on ignition	≤0.1%	0.07%
Loss on drying	≤1.0%	0.29%
Water	≤1.0%	0.21%
Purity (HPLC)	≥99.0%	99.72%
Storage Conditions	Store in a ventilated and dry environment,away from direct sunlight and avoid impact.
Conclusion	The product conforms to the above specifications.

Product Name:RU58841

CAS:154992-24-2

MF:C17H18F3N3O3

Melting point :493.6±55.0 °C(Predicted)
form:powder
color:White
Uses:

RU58841

Also known as PSK-3841 or HMR-3841, RU58841 is a non-steroidal androgen receptor (AR) antagonist originally developed by Roussel Uclaf (France) in the 1980s–1990s. It was designed as a topical treatment for androgen-dependent skin disorders — blocking DHT from binding to androgen receptors in hair follicles and sebaceous glands without reducing systemic hormone levels.

Property	Value
CAS Number	154992-24-2
Molecular Formula	C₁₇H₁₈F₃N₃O₃
Molecular Weight	369.34 g/mol
Chemical Name	4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Appearance	White to off-white crystalline powder
Solubility	Insoluble in water; soluble in DMSO, ethanol, propylene glycol
IC₅₀ (AR binding)	15.9 nM (Sf9 cells); 31–40 nM (MDA-MB-453 cells)

Structural Breakdown

The molecule features a hydantoin (imidazolidinedione) core with a 4-hydroxybutyl side chain, two gem-dimethyl groups, and a 2-(trifluoromethyl)benzonitrile moiety — a strongly electron-withdrawing aromatic group driving high-affinity AR binding. This non-steroidal scaffold is structurally distinct from endogenous steroids, contributing to its tissue-selective profile.

Mechanism of Action

RU58841 acts as a pure competitive antagonist at the androgen receptor. Unlike finasteride (which inhibits 5α-reductase to reduce DHT production), RU58841 blocks DHT from binding to AR directly at the follicular level. It does not alter serum DHT or testosterone levels, and does not interfere with the hypothalamic-pituitary-gonadal axis. Its AR binding affinity is approximately 30 times higher than other non-steroidal antiandrogens like flutamide or Anandron.

Primary Uses

1. Androgenetic Alopecia (Pattern Hair Loss)

The dominant application. In androgenetic alopecia, DHT binds to AR in susceptible scalp follicles, triggering miniaturization — shortening the anagen phase and converting terminal hairs to vellus hairs. By competitively occupying AR at the follicular level, RU58841 interrupts this signal without altering circulating hormones.

Key preclinical evidence:

Stumptailed macaque model (1998): Topical 5% RU58841 significantly outperformed oral finasteride 1 mg/day — follicle count increased by 103 (vs. 88 for finasteride), terminal hair growth by 26 (vs. 12). Serum DHT remained unchanged.

Nude mouse human scalp xenograft (1997): 1% RU58841 applied to balding human scalp grafts significantly increased linear hair growth rates and follicle recycling (28% second cycle vs. 7% control, P < 0.04).

Clinical development: Prostrakan (later renamed) conducted Phase I (30 males, 5% solution, 4 weeks — confirmed safety/tolerability) and Phase II (120 subjects, double-blind, 6 months) trials. Results were reportedly "similar to or better than finasteride," but development was discontinued before Phase III due to commercial considerations — patent expiration concerns and market uncertainty relative to established treatments.

2. Acne Vulgaris

RU58841 was co-developed as a topical acne candidate. Acne is androgen-dependent — sebaceous gland hypertrophy and sebum overproduction are driven by DHT-AR signaling. A prodrug form, RU58841-myristate (RUM), was developed for enhanced follicular targeting. RUM is rapidly converted to active RU58841 by human keratinocytes and sebaceous gland cells (SZ95 line), while showing negligible permeation through intact skin — maximizing local action and minimizing systemic exposure.

3. Hirsutism

Excessive hair growth in androgen-sensitive areas in women is another androgen-dependent condition amenable to topical AR blockade, though development was discontinued before clinical validation.

4. Research Tool Compound

RU58841 serves as a valuable pharmacological tool for studying AR signaling pathways, validating AR antagonist screening assays, investigating tissue-selective anti-androgen action, and hair follicle biology research.

Selling Points & Value Propositions

1. Unique Mechanism — Receptor Blockade Without Hormone Suppression

RU58841's competitive AR antagonism represents a fundamentally different paradigm from oral DHT suppressors:

Does not lower serum DHT or testosterone — animal studies consistently show no change in circulating androgen levels

Does not interfere with the HPG axis — no risk of hormonal feedback disruption

Theoretically lower side effect burden — since systemic androgen signaling is preserved, risks of sexual dysfunction and mood changes associated with oral anti-androgens are minimized

This is particularly attractive to patients who experience or fear the post-finasteride syndrome.

2. Potent In Vitro and In Vivo Efficacy

The compound demonstrates high-affinity AR binding (IC₅₀ ~16 nM) and robust hair growth promotion in multiple animal models. In hamster flank organ assays, topical application at 1 μg/animal produced potent anti-androgenic effects, while doses up to 100 μg/animal showed no systemic anti-androgenic activity and no effect on serum testosterone.

3. Favorable Topical Pharmacokinetic Profile

RU58841 was specifically designed for local action with minimal systemic exposure. The prodrug strategy (RUM loaded on solid lipid nanoparticles) shows negligible skin permeation over 6 hours, further confining activity to the follicular target. A Phase I metabolic study showed that after a single 30 mg topical application, parent compound and metabolites were detectable in systemic circulation, but steroid profile parameters were not affected.

4. Scientific Legacy — Foundation for Next-Generation Topical Anti-Androgens

Although RU58841 itself never reached market, its scientific concept has been validated by subsequent drug development programs:

Clascoterone (Winlevi): FDA-approved for acne (2020), Phase III for AGA with positive results

KX-826 (Pyrumidil): Met its primary endpoint in China's Phase III trial for male AGA (+10.65 hairs/cm² vs. placebo)

GT20029: A PROTAC-based topical AR degrader in Phase II trials

RU58841 is widely recognized as the pioneer molecule that established proof-of-concept for this entire therapeutic class.

5. Versatile Research Reagent

Available from multiple suppliers (MedChemExpress, TCI, BOC Sciences, Chinese manufacturers) at ≥98–99% purity in quantities from 5 mg to 1 kg, suitable for AR binding assays, cell-based reporter gene assays, hair follicle organ culture, and in vivo topical efficacy models.

6. Strong Anecdotal and Community Demand

Despite lacking regulatory approval, RU58841 has developed a significant grassroots following in the hair loss community — active discussion on HairLossTalk, Reddit, and YouTube, with anecdotal reports of reduced shedding and increased thickness. This sustained demand spanning over 15 years reflects the unmet need for effective topical anti-androgen options.

Summary

Aspect	Detail
Identity	Non-steroidal androgen receptor antagonist (CAS 154992-24-2)
Primary use	Topical treatment candidate for androgenetic alopecia, acne, and hirsutism
Mechanism	Competitive AR blockade at follicular level; does not alter serum DHT/testosterone
Potency	IC₅₀ ~16 nM (AR binding); outperformed finasteride in macaque model
Clinical status	Phase II completed (PSK-3841); development discontinued for commercial reasons
Key selling points	Unique receptor-level mechanism; potent preclinical efficacy; favorable topical PK; pioneer of next-gen topical AR antagonists; strong research tool value; sustained community demand
Regulatory status	Research chemical only — not approved for human use
Purity available	≥98–99% for research use

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide RU58841 with good quality and best price, welcome to contact us to get COA/TDS/MSDS of RU58841.

Our Advantages:

1. Guaranteed purity;

2. Large quantity in stock;

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4. Best service after shipment with email;

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Emulsifiers

Humectants

Whitening agent