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Unsaturated hyaluronic acid biose is a disaccharide fragment derived from hyaluronic acid (HA), consisting of Δ4,5-D-glucuronic acid (with a double bond between carbons 4-5) and N-acetyl-D-glucosamine linked via a β-1,3 glycosidic bond. Formed during enzymatic HA degradation (e.g., by hyaluronidase), it serves as a biomarker for HA metabolism and tissue remodeling. The unsaturated bond enhances its reactivity, enabling detection via UV absorption (232 nm) or mass spectrometry. Used in research to study inflammation, osteoarthritis, and wound healing, it also has potential in drug delivery due to its small size and bioactive properties.
Unsaturated hyaluronic acid biose refers to a specific disaccharide unit derived from hyaluronic acid (HA), a natural polysaccharide critical in connective tissues, skin, and synovial fluid. Here's a concise breakdown:
Structure:
D-glucuronic acid (with a 4,5-unsaturated double bond, denoted as Δ4,5-GlcA)
N-acetyl-D-glucosamine (GlcNAc)
Composed of two linked sugars:
Bonded via a β-1,3 glycosidic linkage.
Formation:
Generated during enzymatic degradation (e.g., by hyaluronidase) of hyaluronic acid. The enzyme cleaves HA chains, creating unsaturated bonds at the cleavage site.
Significance:
Acts as a biomarker for HA turnover in tissues.
Used in research to study HA metabolism, inflammation, and tissue remodeling.
Potential applications in drug delivery or regenerative medicine due to its small size and bioactive properties.
Key Feature:
The unsaturated double bond enhances reactivity, enabling detection via UV absorbance (232 nm) or mass spectrometry.
This disaccharide is a fundamental unit for understanding HA breakdown and its role in health and disease.
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