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L-Arginine alpha-Ketoglutarate 2:1 (AAKG) combines two parts L-arginine with one part AKG, offering synergistic benefits across multiple health domains.
In sports nutrition, L-arginine boosts nitric oxide production, enhancing blood flow, nutrient delivery, and muscle pumps during workouts.
For anti-aging and metabolic regulation, AKG fuels the Krebs cycle, improving mitochondrial ATP energy output and activating longevity pathways.
Clinically, AAKG serves as a vital non-protein nitrogen source. AKG accepts amino groups to synthesize essential amino acids, supporting positive nitrogen balance, wound healing, and tissue repair post-surgery.
Furthermore, by maintaining nitrogen balance and stimulating protein synthesis, AAKG effectively reduces muscle catabolism. This makes it highly effective for preserving lean muscle mass during intense training, caloric deficits, or severe physical stress, ensuring faster recovery and sustained physical performance.
Specifications of L-Arginine alpha-Ketoglutarate CAS 5256-76-8 COA:
Items | Specifications | Results |
Appearance(25℃) | White to off-white crystalline powder | Off-White crystalline Powder |
Identification | In accordance with standard retention time | In accordance with standard retention time |
Optical rotation(°) | +16.5~+18.5 | +17.5 |
Solubility | Clear | Clear |
pH | 5.5~7.0 | 5.7 |
Loss on drying(%) | Not more than 1.0 | 0.43 |
Hydrate(%) | Not more than 6.8 | 6.5 |
Residue on ignition(%) | Not more than 0.2 | 0.04 |
Chloride(%) | Not more than 0.05 | Less than 0.05 |
Iron(ppm) | Not more than 10 | Less than 10 |
Heavy Metal(ppm) | Not more than 10 | Less than 10 |
Arsenic(ppm) | Not more than 1 | Less than 1 |
Assay(%) | 98.0~102.0 | 99.8 |
L-Arginine(%) | 65.5~69.0 | 66.28 |
α-Ketoglutarate(%) | 26.5~29.0 | 27.04 |
Total plate counts(cfu/g) | Not more than 1000 | Less than 1000 |
Yeast and Mould(cfu/g) | Not more than 100 | Less than 100 |
Staphylococcus aureus | Absence/g | Complies |
Salmonella | Absence/10g | Complies |
E.coli | Absence/g | Complies |
Storage Condition | Sealed packaging, stored at cool, dry and away from light | |
Conclusion | The product conforms to the above specifications. | |

Product Name:L-Arginine alpha-Ketoglutarate
CAS:5256-76-8
MF:C11H20N4O7
Melting point :N/A
form:crystalline powder
color:off-white
Uses:
L-Arginine alpha-Ketoglutarate 2:1 (AAKG) is a specialized dietary supplement and chemical compound formed by combining two parts L-arginine with one part alpha-ketoglutarate (AKG). This specific 2:1 ratio is designed to maximize the synergistic effects of both components, making it highly valuable in sports nutrition, anti-aging, and clinical recovery.
Sports Nutrition and Fitness
In the fitness industry, AAKG is widely recognized as a pre-workout supplement. L-arginine serves as a precursor to nitric oxide (NO), a potent vasodilator that widens blood vessels. This increases blood flow, delivering more oxygen and nutrients to muscles while flushing out metabolic waste like lactic acid. This process enhances the "muscle pump," boosts endurance, and delays fatigue during high-intensity training.
Anti-Aging and Metabolic Regulation
Alpha-ketoglutarate is a critical intermediate in the Krebs cycle (the cell's energy production pathway). Supplementing AAKG directly fuels mitochondria, improving cellular energy (ATP) output and optimizing overall metabolism. Recent research also links AKG to activating longevity pathways (like AMPK and mTOR), which helps combat cellular aging, supports collagen synthesis, and maintains metabolic health.
Post-Surgery Recovery and Muscle Preservation
In clinical and recovery settings, AAKG acts as an effective non-protein nitrogen source. AKG readily accepts amino groups to synthesize glutamine and other amino acids, promoting a positive nitrogen balance without placing excessive stress on the digestive system. This mechanism is crucial for wound healing and tissue repair post-surgery. Furthermore, by maintaining nitrogen balance and supporting protein synthesis, AAKG effectively reduces muscle catabolism (muscle breakdown), helping patients and athletes preserve lean muscle mass during periods of severe physical stress or caloric deficit.






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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.



Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide L-Arginine alpha-Ketoglutarate 2:1 (AAKG) with good quality and best price, welcome to contact us to get COA/TDS/MSDS of L-Arginine alpha-Ketoglutarate 2:1 (AAKG).
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