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D-Phenylalanine (D-Phe) is the non-proteinogenic, mirror-image form of the essential amino acid L-Phenylalanine. Unlike its L-form, it is not used to build proteins. Its significance lies in its potential to inhibit enzymes that break down the body's natural pain-relieving chemicals (enkephalins). This mechanism has led to its study as a dietary supplement for chronic pain management and depression, though it is not an FDA-approved drug. It is also used in biochemical research to create specific peptide structures.
Items | Specifications | Results |
Appearance | Complies | |
Specific Rotation | +33.0°~ +35.0° | +33.9° |
Loss on drying | ≤0.5% | 0.15% |
Isomer purity | ≤0.1% | 0.02% |
Assay | 98.0~101.0% | 99.4% |
Conclusion | The product by inspection accords with the standard of Enterprise Internal. | |
D-Phenylalanine (D-Phe) is the D-stereoisomer of the essential amino acid phenylalanine.
Amino Acid Basics: Amino acids are the building blocks of proteins. Most amino acids used by the body are in the "L-" form (e.g., L-Phenylalanine).
Stereoisomers: L-Phenylalanine and D-Phenylalanine are mirror images of each other, much like a left and right hand. They have the same chemical formula but different three-dimensional structures.
Unlike its L-form, which is incorporated into proteins, D-Phenylalanine is not used for protein synthesis. Its significance comes from its unique biological activities:
Enkephalin Inhibition: Its primary researched mechanism is its ability to inhibit enzymes called enkephalinases. These enzymes normally break down enkephalins, which are the body's natural pain-relieving chemicals (endorphins). By blocking these enzymes, D-Phenylalanine may increase the level and duration of enkephalin activity, potentially providing an analgesic effect.
Potential Medical Interest:
Pain Management: Because of its mechanism, it has been studied as a potential complementary therapy for chronic pain conditions.
Depression: Some research has explored its use in depression, though evidence is limited.
It is not an FDA-approved drug, but is available as a dietary supplement.
Chemical and Research Applications: It is used in scientific research to create specific peptide structures and study biological pathways involving D-amino acids.
In summary, D-Phenylalanine is the non-proteinogenic, mirror-image form of phenylalanine, studied primarily for its potential role in modulating the body's natural pain-control pathways.
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