Name: China Supplier Ascorbyl glucoside CAS 129499-78-1
Brand: Wuhan Fortuna Chemical Co., Ltd.

Ascorbyl Glucoside: A Comprehensive Overview

1. Chemical Structure and Composition:

Ascorbyl Glucoside is a stable, water-soluble derivative of Vitamin C (ascorbic acid) where a glucose molecule is bonded to ascorbic acid. This glycosidic bond enhances stability and solubility.

2. Stability and Solubility:

Unlike pure L-ascorbic acid, which is prone to oxidation, Ascorbyl Glucoside is more stable in formulations, especially in water-based products, due to its hydrophilic glucose moiety. It does not degrade rapidly when exposed to air or light.

3. Mechanism of Action:

Upon application, skin enzymes (e.g., α-glucosidase) hydrolyze the glucoside bond, releasing active Vitamin C gradually. This controlled release ensures sustained antioxidant activity and minimizes irritation.

4. Skincare Benefits:

Antioxidant Protection: Neutralizes free radicals from UV exposure and pollution.
Collagen Synthesis: Stimulates collagen production, reducing wrinkles and improving elasticity.
Brightening Effect: Inhibits tyrosinase, reducing melanin synthesis to address hyperpigmentation and uneven skin tone.
Gentle Formulation: Suitable for sensitive skin due to its mild nature and slow conversion process.

5. Efficacy and Clinical Support:

Studies indicate effectiveness in improving skin texture, brightness, and reducing photodamage. For example, a 2012 study in International Journal of Cosmetic Science showed significant improvement in skin tone and hydration with 2% Ascorbyl Glucoside.

6. Comparison to Other Vitamin C Derivatives:

Sodium Ascorbyl Phosphate (SAP): More stable than L-ascorbic acid but less potent in collagen synthesis.
Magnesium Ascorbyl Phosphate (MAP): Oil-soluble, ideal for moisturizers; moderate efficacy.
Ethylated Ascorbic Acid: Highly stable and lipid-soluble, with deep penetration.

7. Formulation and Usage:

Commonly found in serums, moisturizers, and sunscreens at concentrations of 0.5–2%. Often paired with other antioxidants (e.g., Vitamin E) or brightening agents (e.g., niacinamide) for synergistic effects.

8. Safety and Regulatory Status:

Generally recognized as safe by the Cosmetic Ingredient Review (CIR). Rarely causes irritation, making it suitable for long-term use across skin types.

9. Storage Considerations:

While more stable than pure Vitamin C, products are still best stored in opaque, airtight containers to prolong shelf life, though less stringent than L-ascorbic acid requirements.

10. Brand Examples:

Featured in products from The Ordinary, Paula’s Choice, and NIOD, often marketed for brightening and anti-aging benefits.

Conclusion: Ascorbyl Glucoside is a versatile, stable Vitamin C derivative ideal for those seeking gentle yet effective antioxidant and anti-aging benefits without the instability of pure ascorbic acid. Its gradual conversion ensures sustained efficacy, making it a popular choice in cosmetic formulations.