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Introduction of Promestriene is a synthetic, topically applied estrogen analog used to treat genitourinary symptoms of menopause (e.g., vaginal dryness, atrophy, painful intercourse). Unlike systemic estrogens, it acts locally on vaginal tissues, stimulating epithelial growth, improving lubrication, and restoring pH balance with minimal systemic absorption, reducing risks like thrombosis or hormonal cancers. Administered as a vaginal cream or ovule (e.g., Colpotrophine®), it’s prescribed for postmenopausal women with vulvovaginal atrophy. Its low systemic exposure makes it safer for those avoiding hormone replacement therapy. Not FDA-approved but available in Europe and Latin America. Contraindicated in estrogen-sensitive cancers. Consult a healthcare provider for use.
Description of Promestriene from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Promestriene | |
Product Name | Promestriene |
CAS NO. | 39219-28-8 |
Apperance | White crystalline powder |
Pacakge | |
MOQ | 1kg |
Storage | |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of Promestriene CAS 39219-28-8
Items | Specifications | Results |
Appearance | White crystalline powder | White crystalline powder |
Identification | positive | positive |
Fusing Range | 64℃~68℃ | 65.9℃~66.2℃ |
Related substance | Single Impurity ≤ 0.1% Total Impurities ≤0.5% | 0.07% 0.17% |
Loss on Drying | ≤0.5% | 0.15% |
Residue on Ignition | ≤0.10% | 0.05% |
Specific Rotation | +64~+71° | +66° |
Heavy Metals | ≤10ppm | Conforms |
Assay | ≥99.5% | 99.83% |
Reside on solution | ethyl alcohol ≤5000ppm ethyl acetate ≤5000ppm | Conforms |
Conclusion | The product meets the requirements | |
Introduction of Promestriene is a synthetic, topically applied estrogen analog used to treat genitourinary symptoms of menopause (e.g., vaginal dryness, atrophy, painful intercourse). Unlike systemic estrogens, it acts locally on vaginal tissues, stimulating epithelial growth, improving lubrication, and restoring pH balance with minimal systemic absorption, reducing risks like thrombosis or hormonal cancers. Administered as a vaginal cream or ovule (e.g., Colpotrophine®), it’s prescribed for postmenopausal women with vulvovaginal atrophy. Its low systemic exposure makes it safer for those avoiding hormone replacement therapy. Not FDA-approved but available in Europe and Latin America. Contraindicated in estrogen-sensitive cancers. Consult a healthcare provider for use.
Application of Promestriene is a synthetic, topically applied estrogen analog primarily used in gynecological treatments. Here's a detailed overview:
Core Structure: A synthetic steroid derivative structurally related to estradiol (a natural estrogen).
Contains a 3-methyl ether group at position 3 (distinguishing it from estradiol).
Molecular Formula: C₁₉H₂₆O₂.
Molecular Weight: 286.4 g/mol.
Mechanism: Acts as a local estrogen receptor agonist, binding to estrogen receptors in vaginal and vulvar tissues.
Absorption: Minimal systemic absorption when applied topically, reducing systemic estrogenic effects.
Solubility: Formulated in creams or vaginal ovules for localized delivery.
1. Primary Use:
Treatment of Genitourinary Syndrome of Menopause (GSM):
Addresses symptoms like vaginal dryness, atrophy, dyspareunia (painful intercourse), and urinary discomfort.
Postmenopausal Vulvovaginal Atrophy: Restores epithelial thickness and lubrication.
2. Advantages Over Systemic Estrogens:
Minimizes systemic exposure, lowering risks of endometrial hyperplasia, thrombosis, or breast cancer associated with oral/hormonal therapies.
Local Estrogenic Activity:
Binds to estrogen receptors in vaginal mucosa, stimulating glycogen production, epithelial proliferation, and blood flow.
Enhances vaginal elasticity, pH normalization, and lubrication.
Topical Cream/Ovules: Applied intravaginally (e.g., 1–2 times weekly).
Brand Names: Marketed as Colpotrophine® (common in Europe and Latin America).
Common Side Effects: Local irritation, itching, or burning (rare).
Systemic Risks: Very low due to minimal absorption; no significant impact on serum estrogen levels.
Contraindications:
Estrogen-sensitive cancers (e.g., breast or endometrial cancer).
Undiagnosed vaginal bleeding.
Approved: In Europe, Latin America, and parts of Asia; not FDA-approved in the U.S.
Prescription Requirement: Yes.
Targeted relief for urogenital atrophy without systemic hormonal risks.
Well-tolerated in patients contraindicated for systemic hormone replacement therapy (HRT).
Promestriene is a niche but valuable option for managing menopausal urogenital symptoms, prioritizing localized efficacy and safety. Always consult a healthcare provider for personalized use.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Promestriene with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Promestriene.
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