Name: China Manufacturer Supply High Quality Best Price 4,4-Difluorocyclohexanol CAS 22419-35-8
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance	Yellow Solid Powder	Qualified
Purity(%)	≥98.0	98.3
Residue on Ignition (%)	≤0.2	0.05
Water Content(%)	≤0.5	0.18
Conclusion	Up to standard of our company.

4,4-Difluorocyclohexanol is an organic chemical compound. You can think of it as a simple ring-shaped structure (cyclohexane) that has been modified in two ways:

Two fluorine atoms are attached to the same carbon atom in the ring.
An alcohol (hydroxyl, -OH) group is attached to a different carbon atom in the ring.

It is primarily used in scientific research and chemical synthesis.

2. Breaking Down the Name

The name describes its molecular structure perfectly:

Cyclohexan- : This indicates a six-carbon ring (cyclohexane), which is not flat but exists in a "chair" conformation.
-ol : This suffix in chemistry means the compound contains an alcohol (hydroxyl, -OH) functional group.
4,4-Difluoro- : This prefix tells us that two fluorine (F) atoms are bonded to the same carbon atom at position #4 of the cyclohexane ring.

In chemical numbering, the carbon with the -OH group is typically designated as carbon #1.

3. Chemical Structure and Properties

Chemical Formula: C₆H₁₀F₂O
Molar Mass: 136.14 g/mol

Key Structural Features:

Ring: The cyclohexane ring is the core scaffold.
Chair Conformation: At room temperature, the molecule predominantly exists in a chair conformation, where the substituents can be equatorial (in the plane of the ring) or axial (perpendicular to it). The hydroxyl group (-OH) is most stable in an equatorial position.
Geminal Difluoride: The two fluorine atoms are attached to the same carbon. This is called a "geminal difluoride" group (geminal means "on the same" atom). This group is highly polar and can significantly alter the molecule's electronic properties and metabolic stability compared to non-fluorinated compounds.

Physical Properties:

It is typically a colorless liquid or a low-melting solid at room temperature.
It has a relatively high boiling point due to hydrogen bonding from the -OH group.
It is moderately soluble in water (due to the -OH group) and highly soluble in common organic solvents like ethanol, diethyl ether, and dichloromethane.

4. Synthesis (How is it made?)

There are several laboratory routes to synthesize 4,4-Difluorocyclohexanol. A common one involves:

Starting Material: Begin with a molecule like 4-hydroxycyclohexanone (which already has the -OH group and a carbonyl group at the correct positions).
Fluorination: Treat the carbonyl group (C=O) at position 4 with a fluorinating reagent, such as Diethylaminosulfur trifluoride (DAST) or Deoxo-Fluor.
Reaction: These reagents replace the oxygen of the carbonyl group with two fluorine atoms, converting the C=O into a CF₂ group.

The chemical reaction is summarized as:
4-Hydroxycyclohexanone + DAST → 4,4-Difluorocyclohexanol

5. Applications and Uses

4,4-Difluorocyclohexanol is not a common consumer product. Its primary importance lies in its role as a chemical building block (synthon) in organic synthesis, especially in the pharmaceutical and agrochemical industries.

Pharmaceuticals: The cyclohexane ring is a very common scaffold in drug molecules. Introducing fluorine atoms is a standard strategy in medicinal chemistry because it can:

Increase Metabolic Stability: The C-F bond is very strong and resistant to being broken down by the body's enzymes, which can prolong the drug's duration of action.
Modify Lipophilicity: Fluorine changes how the molecule interacts with fats and water, which affects its absorption and distribution in the body.
Inhibit Metabolism: Fluorine can block specific sites on a molecule where metabolism would normally occur.

Agrochemicals: Similarly, fluorine-containing compounds are prevalent in the development of herbicides, pesticides, and fungicides.
Material Science: It can be used as a precursor for more complex fluorinated molecules used in specialty polymers or liquid crystals.

Summary

Aspect	Description
Identity	A fluorinated cyclohexanol derivative.
Structure	A six-carbon ring in a chair conformation with an -OH group and a -CF₂- group.
Role	A versatile building block for chemical synthesis.
Key Feature	The geminal difluoride group, which is important for tuning the properties of larger molecules.
Primary Use	Research and development of new pharmaceuticals and agrochemicals.

In essence, 4,4-Difluorocyclohexanol is a valuable and specialized tool for chemists to create more complex and effective fluorinated molecules.