Name: Chemical Manufacturer Supply High Quality 3-Cyanopyridine CAS 100-54-9 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Detailed Description

Specifications of 3-Cyanopyridine CAS 100-54-9 COA:

Items	Specifications	Results
Appearance	White to pale yellow solid	White solid
Assay, w/%	≥ 99.0	99.90
Initial melting point, °C	≥ 48.5	49.8
Loss on drying / Moisture, w/%	≤ 0.20	0.04
Storage Conditions	Store in a ventilated and dry environment,away from direct sunlight and avoid impact.
Conclusion	The product conforms to the above specifications.

Product Name:3-Cyanopyridine

CAS:100-54-9

MF:C6H4N2

Melting point :48-52 °C(lit.)
form:powder
color:White to pale yellow
Uses:

3-Cyanopyridine

Also known as nicotinonitrile or 3-pyridinecarbonitrile, this is a heterocyclic aromatic nitrile — a pyridine ring bearing a cyano group (–C≡N) at the 3-position. It is one of the most important pyridine-based building blocks in industrial organic chemistry, serving as the direct precursor to Vitamin B3 (niacin/nicotinamide) and a wide range of pharmaceutical and agrochemical products.

Property	Value
CAS Number	100-54-9
Molecular Formula	C₆H₄N₂
Molecular Weight	104.11 g/mol
Melting Point	48–52 °C
Boiling Point	~201 °C (sublimes)
Density	1.159 g/cm³
Flash Point	84 °C
Water Solubility	140 g/L (20 °C)
pKa	1.45 (25 °C)
LogP	0.50
SMILES	`N#Cc1cccnc1`
EINECS	202-863-0
HS Code	29333999

Structural Breakdown

The molecule consists of two key features:

Pyridine ring: A six-membered aromatic heterocycle containing one nitrogen atom. This electron-deficient ring governs the compound's solubility, coordination chemistry, and reactivity toward nucleophiles.

Nitrile group (–C≡N) at the 3-position: A strongly electron-withdrawing, highly versatile functional group. It can be hydrolyzed to carboxylic acids or amides, reduced to aminomethyl groups, or participate in cycloaddition reactions — making this compound a multi-directional synthetic platform.

Primary Uses

1. Vitamin B3 Production (Niacin & Nicotinamide)

The single largest application of 3-cyanopyridine is as the direct precursor to nicotinic acid (niacin) and nicotinamide (niacinamide) — collectively known as Vitamin B3. The nitrile group is hydrolyzed under acidic or basic conditions:

3-Cyanopyridine → (hydrolysis) → Nicotinic acid (niacin)

3-Cyanopyridine → (partial hydrolysis) → Nicotinamide

Vitamin B3 is an essential nutrient used in:

Pharmaceuticals — treating pellagra, dyslipidemia, and cardiovascular conditions

Dietary supplements & nutraceuticals — one of the most widely consumed vitamins globally

Food & feed additives — mandatory fortification in many countries

Cosmetics — nicotinamide is a top skincare active ingredient (anti-aging, barrier repair, brightening)

2. Pharmaceutical Intermediates

Beyond Vitamin B3, 3-cyanopyridine is a building block for numerous APIs:

Nicotinyl alcohol (nicotinic acid alcohol ester) — a peripheral vasodilator used to treat vascular disorders

Varenicline (Chantix/Champix) — a smoking-cessation drug that acts as a partial agonist at nicotinic acetylcholine receptors

Anti-inflammatory and anti-cancer agents — the pyridine-nitrile scaffold is incorporated into molecules targeting hypertension, oncology, and neurology

Antibiotics and cardiovascular drugs — the compound's reactivity enables construction of complex heterocyclic drug architectures

3. Agrochemical Intermediates

3-Cyanopyridine is a critical precursor for several crop protection products:

Pymetrozine — a selective insecticide controlling sucking pests (aphids, planthoppers) via a unique "stop-feed" mechanism

2-Chloronicotinic acid — a key building block for neonicotinoid insecticides (e.g., chlorantraniliprole) and other pyridine-based agrochemicals

Rodenticides — intermediate for vacor and cyanophen, used for rodent control

4. Specialty Chemicals & Advanced Materials

Arylthiazolines and arylimidazolines — synthesized via condensation with ethylenediamine or aminoethanethiol, used in drug development

Conductive polymers — cyanopyridine derivatives are explored for OLEDs and photovoltaic cells

Corrosion inhibitors — the pyridine nitrogen coordinates to metal surfaces

Coordination chemistry — both the ring nitrogen and nitrile nitrogen serve as ligands for metal complexation, relevant in catalysis and materials science

Resins, dyes, and pigments — used as intermediate in polymer and colorant synthesis

Selling Points & Value Propositions

1. Multi-Sector Demand Anchor

Unlike single-application intermediates, 3-cyanopyridine sits at the intersection of four massive end-markets simultaneously:

Sector	Key Products
Pharmaceuticals	Vitamin B3, varenicline, nicotinyl alcohol, anti-cancer APIs
Nutraceuticals/Supplements	Niacin, nicotinamide tablets and capsules
Agrochemicals	Pymetrozine, 2-chloronicotinic acid, rodenticides
Food/Feed/Cosmetics	Feed-grade niacinamide, cosmetic-grade nicotinamide

This diversification means demand is resilient — a downturn in one sector (e.g., agrochemicals) is cushioned by stability or growth in others (e.g., vitamins/supplements).

2. Highly Versatile Chemical Reactivity

The nitrile group on the pyridine ring is one of the most chemically transformable functional groups in organic synthesis:

Hydrolysis → nicotinic acid, nicotinamide (Vitamin B3)

Reduction → 3-aminomethylpyridine (used in further drug synthesis)

Grignard addition → pyridyl ketones

Cycloaddition → fused heterocycles (thiazolines, imidazolines)

Coordination → metal-ligand complexes for catalysis

This makes 3-cyanopyridine a platform molecule — a single intermediate that branches into dozens of downstream products, reducing the need for manufacturers to stock multiple starting materials.

3. Mature, Scalable Industrial Production

The dominant industrial route is vapor-phase ammoxidation of 3-methylpyridine:

3-Methylpyridine + NH₃ + Air → (V₂O₅ catalyst, 200–300 °C) → 3-Cyanopyridine + H₂O

This process is:

Well-established at multi-thousand-ton scale

Continuous-process compatible — ideal for modern flow chemistry manufacturing

Cost-efficient — uses inexpensive, commodity feedstocks (3-methylpyridine, ammonia, air)

Amenable to catalyst optimization — ongoing R&D in Cu/Na-loaded Al₂O₃ and other catalysts continues to improve yield and selectivity

Alternative routes (e.g., dehydration of nicotinamide with P₂O₅) exist for smaller-scale or specialty-grade production.

4. Concentrated Supply Base with Reliable Availability

The global market is highly concentrated, with the top 3 producers controlling ~80% of supply:

Rank	Company	Region
1	Vertellus Specialties (incl. Nantong facilities)	USA/China
2	Jubilant Life Sciences	India
3	Lasons India / Shandong Hongda Group	India/China

Other significant players include Yuki Gosei Kogyo (Japan), Lonza Guangzhou (China), Nanjing Guangtong Pharmachemical, Nantong Acetic Acid Chemical, and Hebei Yanuo.

This concentration means:

Supply is predictable — buyers can establish long-term contracts with a small number of reliable partners

Quality consistency is high — major producers maintain ISO certifications and provide full CoAs

China accounts for ~40% of global demand, with India at ~29%, ensuring strong Asia-Pacific supply infrastructure

5. Strong and Growing Global Market

The 3-cyanopyridine market is projected for steady, sustained growth:

Metric	Value
2024 Market Size	~$540 million
2025 Market Size	~$582 million
2031 Forecast	~$800–828 million
CAGR (2025–2031)	5.2–5.5%

Key growth drivers:

Rising Vitamin B3 demand — expanding nutraceutical and supplement markets globally

Pharmaceutical pipeline expansion — new drug candidates incorporating pyridine-nitrile scaffolds

Agrochemical demand in developing regions — Asia, Africa, and Latin America driving crop protection needs

Cosmetic-grade nicotinamide boom — skincare applications growing at double-digit rates

China market growing at ~4.8% annually

6. Favorable Physicochemical Profile for Handling & Formulation

Solid at room temperature (MP 48–52 °C) — easier to handle, weigh, and transport than liquid intermediates

Good water solubility (140 g/L) — simplifies aqueous-phase reactions and workup

Soluble in common organic solvents (ethanol, ether, chloroform, benzene) — compatible with diverse reaction media

Thermally stable — sublimes without decomposition, suitable for high-temperature processes

Stable under normal storage — sealed at room temperature under inert atmosphere

7. Safety Profile Manageable with Standard PPE

GHS Classification: Acute Tox. 4 (oral), Eye Dam. 1, Skin Irrit. 2

Oral LD₅₀ (rat): 1,185 mg/kg — moderately toxic, but not acutely dangerous with proper handling

NIOSH IDLH: 25 mg/m³ — requires respiratory protection in industrial settings

Not classified as carcinogenic or mutagenic

Standard precautions (gloves, goggles, fume hood) are sufficient for safe handling

Summary

Aspect	Detail
Identity	Heterocyclic aromatic nitrile — pyridine-3-carbonitrile (CAS 100-54-9)
Primary uses	Vitamin B3 (niacin/nicotinamide) production; pymetrozine insecticide; varenicline; 2-chloronicotinic acid; rodenticides
Key selling points	Multi-sector demand (pharma, agro, nutrition, cosmetics); highly versatile nitrile reactivity; mature scalable production; concentrated reliable supply; $582M market growing at 5.5% CAGR
Purity available	≥98% (GC), ≥99% for pharmaceutical grade
Market leaders	Vertellus, Jubilant Life Sciences, Lasons India (~80% combined share)
Dominant region	Asia-Pacific (~47% of global market)

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 3-Cyanopyridine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 3-Cyanopyridine.

Our Advantages:

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

5. High quality & competitive price;

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