Name: China Manufacturer Supply High Quality 4-Methoxybenzylamine CAS 2393-23-9
Brand: Wuhan Fortuna Chemical Co., Ltd.

4-Methoxybenzylamine (often abbreviated as PMB-NH₂ or p-Anisylamine) is an organic compound with the chemical formula CH₃OC₆H₄CH₂NH₂. Here's a breakdown of its key aspects:

Chemical Structure:

It consists of a benzylamine core (C₆H₅CH₂NH₂).
A methoxy group (-OCH₃) is attached to the benzene ring at the para position (opposite to the -CH₂NH₂ group). Hence the name *4*-methoxybenzylamine or *p*-methoxybenzylamine.
Structure: CH₃O-C₆H₄-CH₂-NH₂ (where the benzene ring connects OCH₃ and CH₂NH₂ at positions 1 and 4).
Physical Properties:

Appearance: Typically a colorless to pale yellow liquid.
Odor: Characteristic amine odor.
Boiling Point: Around 220-230 °C (428-446 °F).
Density: ~1.06 g/cm³.
Solubility: Soluble in common organic solvents (ethanol, ether, dichloromethane, acetone). Slightly soluble in water, but dissolves readily in acidic water (forming water-soluble salts).
Basicity: It's a primary aliphatic amine (the -NH₂ group is attached to an alkyl chain, -CH₂-, not directly to the aromatic ring), making it moderately basic (pKa of conjugate acid ~9.5).
Other Names:

p-Methoxybenzylamine (PMBA)
(4-Methoxyphenyl)methanamine
p-Anisylamine
4-Anisylamine
Primary Uses:

Carboxylic Acids: Forms stable esters (PMB esters) that can be cleaved selectively under mild acidic conditions (like dichloroacetic acid (DCA) or trifluoroacetic acid (TFA)) or oxidative conditions (DDQ, CAN).
Alcohols & Phenols: Forms stable ethers (PMB ethers) cleavable under similar acidic or oxidative conditions.
Amines: Can be used to protect amines as carbamates (PMB carbamates), cleavable oxidatively.

Organic Synthesis Building Block: Its most significant role is as a versatile precursor or intermediate in synthesizing more complex molecules.
Protecting Group: The 4-Methoxybenzyl (PMB) group, derived from PMB-NH₂ (often via PMB-Cl or PMB-OH), is widely used as a protecting group in organic synthesis, particularly for:
Pharmaceutical Intermediates: Used in the synthesis of various drugs, including migraine medications (e.g., Sumatriptan, Almotriptan, Eletriptan), antibacterial agents, and other bioactive molecules.
Agrochemical Intermediates: Used in the synthesis of certain pesticides and herbicides.
Corrosion Inhibitors: Used in some formulations.
Chemical Research: A common reagent in research labs for developing new synthetic methods or studying reaction mechanisms.
Safety and Handling:

Corrosive: Causes severe skin burns and eye damage.
Toxic: Harmful if swallowed, in contact with skin, or inhaled.
Flammable: Combustible liquid.
Environmental Hazard: Toxic to aquatic life.
Handling: Requires strict precautions: Use in a well-ventilated fume hood, wear appropriate PPE (gloves, goggles, lab coat), avoid contact with skin/eyes, avoid breathing vapors/mist. Store in a cool, dry, well-ventilated place away from oxidizers and acids.

In Summary: 4-Methoxybenzylamine is a commercially important aromatic amine primarily valued as a key building block and the source of the PMB protecting group in organic synthesis, especially for pharmaceuticals. Its reactivity stems from the primary amine group (-NH₂) and the electron-donating methoxy group on the aromatic ring. Handle it with care due to its corrosive and toxic nature.