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Introduction of Sodium diatrizoate hydrate is an iodinated, water-soluble contrast agent used in diagnostic imaging. Its structure features a benzene ring with three iodine atoms (providing X-ray opacity), two acetamido groups, and a sodium carboxylate group, enhancing solubility. Administered intravenously, orally, or rectally, it highlights blood vessels, urinary tracts, or gastrointestinal systems during X-rays or CT scans. A high-osmolar ionic agent, it carries risks like nephrotoxicity or allergic reactions, limiting its use compared to safer non-ionic alternatives. Still employed in specific GI studies (e.g., Gastrografin), it requires proper hydration and kidney function assessment. Store protected from light/moisture.
Description of Sodium diatrizoate hydrate from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Sodium diatrizoate hydrate | |
Product Name | Sodium diatrizoate hydrate |
CAS NO. | 737-31-5 |
Apperance | White powder |
Assay | 99.88% |
Pacakge | 1kg/Foil Bag, 25kg/ Box/carton |
MOQ | 1kg |
Storage | |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of Sodium diatrizoate hydrate CAS 737-31-5
Items | Specifications | Results |
Appearance | White powder | White powder |
Assay | ≥99.0% | 99.88% |
Identify (HPLC) | Retention time of the principal peak in sample should match retention time of standard principal peak in HPLC | Conforms |
Water Content (Halogen moisture meter - Loss on drying), max | 4.0～8.0% | 4.85% |
PH value (10% aqueous solution) | 7.0～10.0% | 8.12 |
Solubility (10%, 25% or 50% aqueous solution) | Clear, colorless, no black spots and no suspended solids | Pass-test |
Conclusion | up to Standard | |
Introduction of Sodium diatrizoate hydrate is an iodinated, water-soluble contrast agent used in diagnostic imaging. Its structure features a benzene ring with three iodine atoms (providing X-ray opacity), two acetamido groups, and a sodium carboxylate group, enhancing solubility. Administered intravenously, orally, or rectally, it highlights blood vessels, urinary tracts, or gastrointestinal systems during X-rays or CT scans. A high-osmolar ionic agent, it carries risks like nephrotoxicity or allergic reactions, limiting its use compared to safer non-ionic alternatives. Still employed in specific GI studies (e.g., Gastrografin), it requires proper hydration and kidney function assessment. Store protected from light/moisture.
Application of Sodium diatrizoate hydrate is a pharmaceutical compound primarily used as an iodinated contrast agent in diagnostic radiology. Below is a detailed breakdown of its properties, structure, and applications:
Core Compound: Diatrizoic acid derivative (a triiodinated benzoic acid).
Structure:
A benzene ring substituted with:
Three iodine atoms (at positions 2, 4, and 6) for radiopacity.
Two acetamido groups (-NHCOCH₃) at positions 3 and 5.
A carboxyl group (-COO⁻) at position 1, neutralized by a sodium ion (Na⁺).
Hydrate: Contains water molecules (H₂O) in its crystalline lattice (exact stoichiometry varies).
IUPAC Name: Sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate hydrate.
1. High Water Solubility: The sodium salt form enhances solubility, making it suitable for intravenous or oral administration.
2. Radiopacity: Contains ~60% iodine by weight, enabling strong X-ray absorption for imaging.
3. Osmolality: Classified as a high-osmolar contrast medium (HOCM), which may cause more side effects compared to newer low-osmolar agents.
4. Stability: The hydrate form ensures stability in solid-state storage but requires protection from light and moisture.
Diagnostic Imaging:
Angiography: Visualizes blood vessels.
Urography: Examines the urinary tract.
Gastrointestinal Studies: Used orally or rectally for GI tract imaging (e.g., barium substitute).
Administration: Typically administered intravenously, orally, or via enema, depending on the procedure.
Mechanism: Iodine atoms absorb X-rays, creating contrast between tissues and fluids.
Excretion: Eliminated renally (unchanged) within 24 hours; requires normal kidney function.
Adverse Effects:
Mild: Nausea, flushing, or itching.
Severe: Anaphylaxis, nephrotoxicity (rare, but caution in renal impairment).
Contraindications: Allergy to iodine, severe renal dysfunction, or hyperthyroidism.
High-Osmolar vs. Low-Osmolar: Sodium diatrizoate is an older ionic, high-osmolar agent (higher risk of adverse reactions). Newer non-ionic agents (e.g., iohexol, iopamidol) are safer but more expensive.
Brand Names: Historically marketed as Hypaque (in combination with meglumine diatrizoate) or Gastrografin (for GI use).
Store in airtight containers, protected from light and humidity.
Solutions are typically prepared just before use to avoid degradation.
Sodium diatrizoate hydrate is a legacy iodinated contrast agent valued for its radiopacity but limited by high osmolality. It remains in use for specific applications (e.g., GI imaging) but has largely been replaced by safer non-ionic alternatives in vascular studies.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Sodium diatrizoate hydrate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Sodium diatrizoate hydrate.
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