Name: China Manufacturer Supply High Quality Calcipotriol Monohydrate CAS 147657-22-5
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance	White or off-white crystalline powder	White or off-white crystalline powder
Water	3.3%-5.0%	4.30%
Assay	97.0%-102.0%	100.00%
solubleness	It is almost insoluble in water, readily soluble in ethanol（96%）, and slightly soluble in dichloromethane	Conformity
Identification of A Infrared	The infrared spectrum of the test sample is consistent with that of the reference substance	Conformity
Identify B liquid chromatography	The retention time of the main peak of the test sample was consistent with that of the reference substance	Conformity
Substance A: Thin-layer chromatography TLC	ImpurityA NMT0.25%	not detected
Substance A: Thin-layer chromatography TLC	Impurity G or impurity H and their sum NMT0.25%	not detected
Substance A: Thin-layer chromatography TLC	Other individual impurities shall not exceed 0.1% NMT0.1%	not detected
Substance B: Liquid chromatography (HPLC)	ImpurityB NMT0.5%	0.10%
Substance B: Liquid chromatography (HPLC)	ImpurityC NMT1.0%	0.10%
Substance B: Liquid chromatography (HPLC)	ImpurityD NMT1.0%	0.30%
Substance B: Liquid chromatography (HPLC)	Purity NLT 97.5%	99.40%
Substance B: Liquid chromatography (HPLC)	total impurities NMT 2.5%	0.60%
Residual solvent	Tetrahydrofuran NTM720ppm	137ppm
Residual solvent	methyl alcohol NTM3000ppm	not detected
Residual solvent	ethyl alcohol NTM5000ppm	not detected
Conclusion	The product conforms to the above specifications.

Calcipotriol Monohydrate is a synthetic analog of vitamin D₃ (cholecalciferol) engineered to retain therapeutic potency while minimizing the hypercalcemic side effects of natural vitamin D. Chemically, it differs from endogenous vitamin D₃ by a hydroxyl group at the 24-position and a double bond in the side chain, optimizing its affinity for vitamin D receptors (VDRs) in skin cells.

Mechanistically, it exerts anti-psoriatic effects by binding to VDRs in keratinocytes and immune cells: it inhibits abnormal keratinocyte proliferation, promotes normal differentiation (restoring skin barrier function), and suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6) and immune cell infiltration—addressing the core pathogenic features of psoriasis.

Clinically, it is a first-line topical therapy for mild-to-moderate plaque psoriasis, available as ointments, creams, gels, or foams for targeted application to lesions (scalp, body). It is often combined with topical corticosteroids (e.g., betamethasone) to enhance efficacy and reduce irritation. Beyond psoriasis, it is being investigated for other hyperproliferative skin conditions (e.g., vitiligo, ichthyosis) due to its regulatory effects on skin cell turnover.

Formulation-wise, it requires stability considerations (protected from light/heat) and is formulated for low systemic absorption, ensuring safety for long-term use. Its role in dermatology underscores its value as a targeted, patient-friendly alternative to systemic therapies for chronic skin disorders.