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Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Bufexamac with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Bufexamac.
Description of Bufexamac from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Bufexamac | |
Product Name | Bufexamac |
CAS NO. | 2438-72-4 |
Apperance | Almost white crystalline powder, slightly effluvial,tasteless |
Assay | 98.4% |
Pacakge | 1kg/Foil Bag,25kg/Drum/Box |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of High Purity 98.4% Wholesales price Bufexamac Powder CAS NO 2438-72-4 Active Pharmaceutical Ingredients API
Items | Specifications | Results |
Appearance(25℃) | White or off-white crystalline powder, odorless | Complies |
IR | Should be consistent with that of the reference product | Complies |
UV absorption | This product should have maximum absorption at wavelengths of 227 ± 2nm, 277 ± 2nm, and 283 ± 2nm | Complies |
Solubility | This product is soluble in dimethylformamide, slightly soluble in ethanol and methanol, and almost insoluble in water and ether | Complies |
Melting point | 162-168℃, Simultaneous decomposition during melting | 164.6℃, Simultaneous decomposition during melting |
Loss on drying | ≤0.5% | 0.2% |
Residue on ignition | ≤0.1% | 0.03% |
Related Substances | The total area of impurity peaks in the chromatogram of the test solution shall not exceed 1.0% of the main peak area of the control solution | 0.48% |
Heavy metals | ≤10ppm | Complies |
As | ≤2ppm | Complies |
Assay | Calculated as anhydrous substance, this product should contain ≥98.5% styrene butadiene hydroxy acid | 99.1% |
Conclusion | The product conforms to the above specifications. | |
Ues：
Bufexamac (Chinese name: 丁苯羟酸) is a non-steroidal anti-inflammatory drug (NSAID) that was historically used as a topical agent to treat inflammatory skin conditions, such as eczema, dermatitis, sunburns, and minor burns.
However, it is crucial to know that Bufexamac has been withdrawn from the market in many countries (including the US, Canada, the EU, Australia, Japan, and New Zealand) due to a high risk of severe allergic contact dermatitis and questionable clinical efficacy.
Historical Uses
Topical Treatment: It was formulated as a 5% cream or ointment to treat subacute and chronic eczema, atopic dermatitis, and other inflammatory skin conditions.
Symptom Relief: It was used to relieve itching, sunburns, thermal burns, and insect bites.
Proctological Use: In some regions, it was manufactured as a suppository (often combined with local anesthetics) for treating hemorrhoids and anal fissures.
Historical Selling Points (Theoretical Advantages)
Before its withdrawal, the "selling points" or perceived benefits of Bufexamac included:
Non-Steroidal Alternative: As an NSAID, it provided a non-corticosteroid option for treating skin inflammation, which was appealing for patients wanting to avoid the side effects of topical steroids.
Targeted Action: It worked by inhibiting the cyclooxygenase (COX) enzyme, thereby blocking the production of prostaglandins (chemicals that cause inflammation and pain) directly at the application site.
Low Systemic Absorption: When applied topically, it achieved high concentrations in local tissues with very little entering the bloodstream, theoretically minimizing systemic side effects.
Wound Healing: Studies suggested it was unlikely to negatively affect wound healing.
Why It Was Banned (Critical Safety Warning)
Despite its initial uses, Bufexamac is no longer recommended or sold in most major markets because:
High Allergy Risk: It is a well-recognized and potent cause of allergic contact dermatitis. In some patient populations (like those with eczema), the severe allergic reaction rate was significant.
Misdiagnosis: The allergic reaction it caused often looked identical to the skin condition (like eczema) it was supposed to be treating, leading to delayed treatment and worsening of symptoms.
Lack of Efficacy: Later clinical trials failed to prove its effectiveness, leading regulatory bodies like the European Medicines Agency (EMA) to conclude that its risks far outweighed its benefits.
Disclaimer: If you are currently using a product containing Bufexamac and experience worsening skin redness, blistering, or itching, stop using it immediately and consult a healthcare professional.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Bufexamac with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Bufexamac.
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