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Introduction of 1-Bromo-3,5-diiodobenzene (C₆H₃BrI₂) is a halogenated aromatic compound with a benzene ring substituted by bromine at position 1 and iodine at positions 3 and 5. Its electron-withdrawing halogens deactivate the ring, directing reactivity toward electrophilic substitution. The differing bond strengths of C–Br and C–I make it valuable in cross-coupling reactions (e.g., Suzuki, Ullmann), where iodine reacts faster than bromine, enabling selective synthesis. Used as a building block in pharmaceuticals, agrochemicals, and materials, its meta-substitution pattern aids regioselective functionalization. Handle with care—toxic, light-sensitive, and requires proper disposal. Key in designing complex molecules via controlled halogen reactivity.
Description of 1-BROMO-3,5-DIIODOBENZENE from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of 1-BROMO-3,5-DIIODOBENZENE | |
Product Name | 1-BROMO-3,5-DIIODOBENZENE |
CAS NO. | 149428-64-8 |
Apperance | Light yellow to light brown (Solid) |
Assay | 98.82% |
Pacakge | 1kg/Foil Bag, 25kg/ Box/carton |
MOQ | 1kg |
Storage | 2-8°C, protect from light |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of 1-BROMO-3,5-DIIODOBENZENE CAS 149428-64-8
Items | Specifications | Results |
Appearance | Light yellow to light brown (Solid) | Light yellow to light brown (Solid) |
1 H NMR Spectrum | Consistent with structure | Consistent with structure |
Purity (HPLC) | ≥98.0% | 98.82% |
Conclusion | The product has been tested and complies with the given specifications. | |
Introduction of 1-Bromo-3,5-diiodobenzene (C₆H₃BrI₂) is a halogenated aromatic compound with a benzene ring substituted by bromine at position 1 and iodine at positions 3 and 5. Its electron-withdrawing halogens deactivate the ring, directing reactivity toward electrophilic substitution. The differing bond strengths of C–Br and C–I make it valuable in cross-coupling reactions (e.g., Suzuki, Ullmann), where iodine reacts faster than bromine, enabling selective synthesis. Used as a building block in pharmaceuticals, agrochemicals, and materials, its meta-substitution pattern aids regioselective functionalization. Handle with care—toxic, light-sensitive, and requires proper disposal. Key in designing complex molecules via controlled halogen reactivity.
Application of 1-Bromo-3,5-diiodobenzene is a halogenated aromatic compound with the molecular formula C₆H₃BrI₂. Below is a detailed breakdown of its structure, properties, and applications:
Substituents: A benzene ring substituted with:
1 bromine atom (Br) at position 1.
2 iodine atoms (I) at positions 3 and 5.
IUPAC Name: The name follows standard nomenclature rules. While iodine has higher priority than bromine for numbering, the given name reflects the substituent positions as specified (*1-bromo-3,5-diiodobenzene*). Note that under strict IUPAC rules, numbering might prioritize iodine, but the name here is consistent with the user’s query.
Appearance: Likely a crystalline solid (common for polyhalogenated aromatics).
Molecular Weight: ~437.81 g/mol (Br: 79.9, I: 126.9 × 2).
Solubility: Insoluble in water; soluble in organic solvents (e.g., dichloromethane, THF).
Electron Effects: The electron-withdrawing halogens deactivate the ring toward electrophilic substitution.
1. Cross-Coupling Reactions:
Iodine and bromine serve as leaving groups in reactions like:
Suzuki coupling (palladium-catalyzed aryl-aryl bond formation).
Ullmann coupling (copper-mediated aryl halide coupling).
Iodine typically reacts faster than bromine due to weaker C–I bonds.
2. Nucleophilic Aromatic Substitution:
Possible under harsh conditions (e.g., strong bases or high temperatures).
3. Directed Metalation:
Halogens can direct lithiation or other metalation reactions for further functionalization.
Halogenation Strategies:
1. Stepwise Halogenation:
Start with iodination of benzene (e.g., using I₂/HNO₃ or directed metalation), followed by bromination.
2. Halogen Exchange:
Replace existing substituents (e.g., nitro groups) via Sandmeyer or Finkelstein reactions.
Organic Synthesis:
Building block for pharmaceuticals, agrochemicals, or materials (e.g., liquid crystals).
Enables selective functionalization due to differing halogen reactivity.
Coordination Chemistry:
Potential ligand for metal complexes (e.g., Pd or Cu catalysts).
Toxicity: Halogenated aromatics may be toxic or irritants.
Precautions: Use gloves, goggles, and work in a fume hood.
Disposal: Follow regulations for halogenated organic waste.
Regioselectivity: The meta-substitution pattern (3,5-diiodo) influences further reactions.
Stability: Light-sensitive (iodine may degrade under UV light); store in dark containers.
This compound’s unique halogenation pattern makes it valuable in synthetic chemistry for designing complex molecules with precise substitution patterns. Always verify its structure and numbering in specific applications!
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 1-BROMO-3,5-DIIODOBENZENE with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 1-BROMO-3,5-DIIODOBENZENE.
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