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Polyhexamethylene biguanidine hydrochloride (PHMB) is used as a pharmaceutical intermediate.
Polyhexamethylene biguanidine hydrochloride (PHMB) is a cell membrane active antibacterial agent, it has a higher inhibitory effect on bacterial activity than that of fungi, and its antibacterial mechanism is roughly as follows: first PHMB is a polycationic compound, which will be adsorbed on the surface of negatively charged microorganisms to prevent its division and reproduction, while the PHMB adsorbed on the surface of microorganisms acts on the phospholipid bilayer in the cytoplasm through transmembrane transport, and binds to negatively charged phosphate groups, thereby changing the selective permeability of cell membranes, destroying cell metabolism, thereby killing microorganisms.
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