Specifications of Chlorogenic acid CAS 327-97-9 COA:

Items	Specifications	Results
Appearance(25℃)	Light Yellow Brown Powder	Conforms
Odour	Characteristic	Conforms
Taste	Characteristic	Conforms
Chlorogenic Acids (HPLC)	Min. 50%	50.8%
Caffeine(HPLC)	Max. 2%	0.7%
Particle Size	Min. 95% pass 80 mesh	80 mesh screen
Loss of Drying	Max. 5%	2.4%
Acid insoluble ash	Max. 5%	0.1%
Heavy Metals	Max. 10 ppm	＜10 ppm
Lead	Max. 3 ppm	＜1 ppm
Arsenic	Max. 2 ppm	＜1 ppm
Cadmium	Max. 1 ppm	＜1ppm
Mercury	Max. 0.1 ppm	＜0.1 ppm
Ethanol Residue	Max. 5000 ppm	Conforms
Total Aerobic	Max. 1000 CFU/g	＜100 CFU/g
Mold and Yeast	Max. 100 CFU/g	＜10 CFU/g
E. Coli	Negative/1g	Conforms
Salmonella/25g	Negative/25g	Conforms
Storage	Store in cool, dry, enclosed, clean storage areas. Away from strong direct light.
Packing	Packed in paper-drums with two food grade plastic-bags inside, N.W.25Kg/Drum.
Conclusion	The product conforms to the above specifications.

Product Name:Chlorogenic acid

CAS:327-97-9

MF:C16H18O9

Melting point :210 °C (dec.) (lit.)
form:powder
color:Light Yellow Brown

Uses:

Applications of Chlorogenic Acid in Food

Name: Supplier Sport Food Grade High Quality Best Price Chlorogenic acid CAS 327-97-9 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Chlorogenic Acid — Glucose Absorption Inhibitor for Slimming & Body Shaping

CAS No.: 327-97-9

Chlorogenic Acid (CGA) is a naturally occurring polyphenolic compound formed by the esterification of caffeic acid and quinic acid. It is widely recognized as one of the most abundant dietary polyphenols in the human diet, predominantly found in green coffee beans (unroasted Coffea species), where it constitutes up to 70% of the total polyphenol content. It is also present in apples, pears, blueberries, tea leaves, honeysuckle, eucommia bark, and various other plant-based foods. CGA is the principal bioactive compound responsible for the metabolic health benefits associated with coffee consumption, independent of caffeine.

Core Mechanism: Inhibition of Glucose Absorption

CGA's primary mechanism in the context of body shaping and slimming centers on its ability to inhibit glucose absorption through multiple coordinated pathways:

Inhibition of α-glucosidase and α-amylase: CGA acts as a competitive, non-reversible inhibitor of intestinal α-glucosidase — the enzyme responsible for the final hydrolysis of disaccharides and oligosaccharides into absorbable glucose monomers in the small intestine. By blocking this enzyme, CGA significantly delays carbohydrate digestion and reduces the rate and extent of glucose entry into the bloodstream, effectively blunting postprandial blood glucose spikes.
Inhibition of sodium-glucose cotransporter 1 (SGLT-1): CGA reduces the expression and activity of SGLT-1, the primary transporter responsible for active glucose uptake across the intestinal epithelium, further limiting the total amount of dietary glucose that reaches systemic circulation.
Suppression of hepatic glucose output: CGA inhibits glucose-6-phosphatase (G6Pase), the rate-limiting enzyme in hepatic gluconeogenesis and glycogenolysis, reducing the liver's contribution to circulating glucose levels — particularly important during fasting states and overnight metabolic regulation.
Activation of AMPK pathway: CGA activates AMP-activated protein kinase (AMPK), a master metabolic regulator that enhances peripheral glucose uptake in skeletal muscle via GLUT4 translocation, improves insulin sensitivity, and simultaneously promotes fatty acid oxidation while suppressing lipogenesis.

Functional Benefits in Slimming & Body Shaping

Reduced Caloric Absorption from Carbohydrates: By inhibiting carbohydrate-digesting enzymes and intestinal glucose transporters, CGA effectively reduces the net caloric load from dietary carbohydrates. Clinical studies have demonstrated that CGA-enriched coffee reduces glucose absorption by approximately 6.9% compared to control, translating into meaningful caloric deficit over time — a fundamental driver of fat loss and body shaping.
Visceral Fat Reduction & Body Composition Improvement: Clinical trials have shown that CGA supplementation (200–400 mg/day from green coffee extract) over 8–12 weeks leads to significant reductions in body weight (average 4.97 kg vs. 2.45 kg placebo), body mass index, waist circumference, and visceral fat mass. Importantly, CGA-supplemented groups showed a greater increase in lean mass-to-fat mass ratio, indicating preferential fat loss with muscle preservation — the hallmark of effective body shaping.
Appetite Regulation via Hypothalamic Modulation: CGA has been shown to suppress orexigenic (appetite-stimulating) neuropeptides including NPY and AgRP in the hypothalamus, while upregulating anorexigenic (satiety-promoting) peptides such as POMC and CARTPT. This central appetite-regulating effect helps reduce caloric intake without the psychological burden of hunger — a critical advantage for sustained adherence to caloric deficit protocols.
Adipogenesis Inhibition & Fat Browning: CGA suppresses the differentiation of preadipocytes into mature fat cells by downregulating master adipogenic transcription factors including PPARγ, C/EBPα, and SREBP-1c. Simultaneously, CGA promotes the "browning" of white adipose tissue — increasing the expression of thermogenic markers such as UCP1, PGC-1α, and PRDM16 — thereby enhancing non-shivering thermogenesis and increasing daily energy expenditure.
Lipid Metabolism Optimization: CGA significantly reduces serum triglycerides, total cholesterol, and LDL-cholesterol while elevating HDL-cholesterol. It achieves this by upregulating hepatic PPARα (promoting fatty acid β-oxidation), inhibiting HMG-CoA reductase (reducing cholesterol synthesis), and enhancing carnitine palmitoyltransferase (CPT) activity (accelerating mitochondrial fatty acid transport). These effects collectively reduce adipose tissue accumulation and support a leaner body composition.
Anti-Inflammatory & Antioxidant Support: Chronic low-grade inflammation in visceral adipose tissue is a key driver of insulin resistance and metabolic dysfunction. CGA suppresses NF-κB-mediated inflammatory signaling, reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and activates the Nrf2/HO-1 antioxidant pathway — restoring metabolic homeostasis and creating a physiological environment conducive to fat loss and lean tissue preservation.

Differentiation from Other Weight Management Ingredients

Unlike stimulant-based fat burners (e.g., caffeine, synephrine) that primarily work through catecholamine-driven thermogenesis and lipolysis, CGA operates through a glucose-blocking, metabolic-modulating mechanism that addresses the root cause of fat accumulation — excessive carbohydrate absorption and insulin-driven lipogenesis. This makes CGA particularly suitable for:

Non-stimulant weight management formulations (ideal for evening use or stimulant-sensitive individuals)
Pre-meal carbohydrate-blocking supplements (taken 30 minutes before carbohydrate-rich meals)
Green coffee extract-based slimming capsules and powders (standardized to 40–50% CGA content)
Functional beverages and meal replacement shakes targeting blood sugar control and satiety
Clean-label body shaping stacks (combined with L-carnitine, CLA, or fiber-based satiety ingredients)

CGA has emerged as a cornerstone ingredient in the weight management and body shaping category

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Chlorogenic acid with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Chlorogenic acid.

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