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5-Amino-2-chloropyridine is an organic compound and a substituted pyridine. It features a chlorine atom and an amino group attached to its six-membered ring. This structure makes it a versatile bifunctional building block in synthetic chemistry. The chlorine site is prone to displacement reactions, while the amino group can be modified. It is primarily used as a key intermediate in pharmaceutical synthesis for creating more complex molecules, including various active drug ingredients and agrochemicals. Its reactivity allows for selective, stepwise construction of sophisticated chemical architectures.
5-Amino-2-chloropyridine is an organic compound belonging to the pyridine family, a class of heterocyclic compounds important in medicinal and industrial chemistry. Its structure consists of a pyridine ring (a six-membered ring with five carbon atoms and one nitrogen atom) substituted with an amino group (-NH₂) at the 5-position and a chlorine atom (-Cl) at the 2-position.
This combination of an electron-donating amino group and an electron-withdrawing chlorine atom makes it a versatile building block (synthon) in chemical synthesis.
Key Properties and Uses:
Bifunctional Reactivity: The chlorine atom is reactive in nucleophilic substitution reactions, while the amino group can be modified (e.g., diazotization, acylation). This allows chemists to selectively functionalize the molecule.
Pharmaceutical Intermediate: It is a key raw material and intermediate in the synthesis of various active pharmaceutical ingredients (APIs) and agrochemicals.
Ligand and Catalyst: It can be used to create ligands for metal complexes in catalysis.
Appearance: It typically appears as a beige to light brown crystalline powder.
In short, 5-Amino-2-chloropyridine is a valuable synthetic intermediate prized for its two reactive sites, which enable the construction of more complex molecules, particularly in the pharmaceutical industry.
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