Specifications of 4-Acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine CAS 136738-23-3 COA:

Items	Specifications	Results
Appearance	White or light yellow powder	Qualified
Content(HPLC)	≥98.00%	98.75%
Moisture	≤8.00%	7.80%
PH	6-8	6.7
Storage Conditions	Store in a ventilated and dry environment,away from direct sunlight and avoid impact.
Conclusion	The product conforms to the above specifications.

Product Name:N-(6-Methyl-3-oxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl)acetamide

CAS:136738-23-3

MF:C6H10N4O2

Melting point :N/A
form:powder
color:White or Light Yellow
Uses:

4-Acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine

What Is This Compound?

Also known as triazine amide , this is a nitrogen-rich heterocyclic amide belonging to the tetrahydro-1,2,4-triazine family. It serves as a critical intermediate in the multi-step synthesis of pymetrozine, a globally important selective insecticide.

Property	Value
CAS Number	136738-23-3
Molecular Formula	C₆H₁₀N₄O₂
Molecular Weight	170.17 g/mol
Density	~1.43 g/cm³ (predicted)
pKa	11.22 ± 0.40 (predicted)
Appearance	White to off-white crystalline powder
Solubility	Sparingly soluble in water; soluble in ethanol, dichloromethane
Shelf Life	3 years (sealed, cool, dry storage)

Structural Breakdown

The molecule features a partially saturated 1,2,4-triazine ring (a six-membered ring containing three nitrogen atoms) bearing:

Position 3 — Ketone (C=O): Provides hydrogen-bonding capability and contributes to the ring's electronic character

Position 4 — Acetylamino group (–NHCOCH₃): The key functional handle that is later hydrolyzed to a free amine (–NH₂) during pymetrozine synthesis

Position 6 — Methyl group (–CH₃): A small lipophilic substituent that modulates steric and electronic properties

Primary Use: Key Intermediate for Pymetrozine

The dominant commercial application of this compound is as a direct precursor to pymetrozine (CAS 123312-89-0), a selective, non-lethal insecticide originally developed by Ciba-Geigy (now Syngenta) in 1988.

What Is Pymetrozine?

Pymetrozine is a pyridine/triazinone-class insecticide that controls sucking pests — aphids, whiteflies, planthoppers, and leafhoppers — through a unique "stop-feed" mechanism. Rather than killing insects through neurotoxicity, pymetrozine causes irreversible stylet blockage: the moment a pest contacts the compound, its mouthparts become blocked, it ceases feeding immediately, and eventually dies from starvation. This makes it:

Highly selective — nearly harmless to beneficial insects (ladybugs, lacewings, spiders)

Excellent systemic activity — 2–3× more potent than pirimicarb and 140× more than cypermethrin in translaminar uptake

Effective against resistant strains — controls pests resistant to organophosphates and carbamates

Blocks virus transmission — by stopping feeding instantly, it prevents insects from transmitting plant viruses

Pymetrozine is used extensively on rice, cotton, vegetables, wheat, and fruit trees, particularly for controlling rice planthoppers and aphids. Asia is the largest market (61.6% of global sales), with rice as the dominant crop (24.2% of total).

How This Intermediate Fits into the Synthesis

The standard industrial synthesis of pymetrozine follows a 6-step route starting from ethyl acetate:

Ethyl acetate + hydrazine hydrate → Acethydrazide

Acethydrazide + phosgene → 2-Methyl-1,3,4-oxadiazol-5(4H)-one (oxadiazolone)

Oxadiazolone + chloroacetone → Alkylated oxadiazolone

Alkylated oxadiazolone + hydrazine hydrate → 4-Acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine (THIS COMPOUND)

This compound + HCl → 4-Amino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine (aminotriazinone)

Aminotriazinone + nicotinaldehyde → Pymetrozine

This compound is formed in Step 4 via ring expansion — the hydrazine opens the five-membered oxadiazolone ring and re-closes it as a six-membered triazine ring through hydrazone condensation. It is then acid-hydrolyzed in Step 5 to remove the acetyl protecting group, yielding the free amine (aminotriazinone), which undergoes condensation with nicotinaldehyde in Step 6 to form pymetrozine's characteristic pyridylmethyleneamino side chain.

An optimized process achieves 96% yield for this compound at 99% HPLC purity, and the subsequent conversion to pymetrozine achieves 91.3% yield from this intermediate.

Selling Points & Value Propositions

1. Indispensable Gateway to a High-Value Insecticide

This compound sits at the narrowest bottleneck of pymetrozine production. Every industrial route to pymetrozine — whether the traditional ethyl acetate route, the trifluoroethyl acetate route, or newer green alternatives — must pass through this triazine amide intermediate or its direct equivalent. With pymetrozine being a globally registered, multi-hundred-ton-per-year insecticide, demand for this intermediate is structurally underpinned by large-scale agricultural need.

2. Nitrogen-Rich Heterocyclic Scaffold with Versatile Reactivity

The 1,2,4-triazine core is a privileged scaffold in medicinal and agrochemical chemistry. Its three nitrogen atoms create multiple sites for:

Ring-opening and re-functionalization

Coordination to metal centers (useful in catalysis)

Hydrogen bonding with biological targets

This makes the compound valuable beyond pymetrozine — it can serve as a building block for novel triazine-based drug candidates and other agrochemicals.

3. Established, Scalable Manufacturing with Multiple Routes

Several patented and published processes exist for producing this compound at industrial scale:

Traditional route (ethyl acetate → oxadiazolone → alkylation → hydrazine ring expansion): Well-proven at 500+ ton/year scale with ~50% overall pymetrozine yield

Green route (dimethyl carbonate → carbohydrazide → condensation → cyclization): Avoids toxic phosgene, shorter synthesis, ~65% overall yield, lower waste

The availability of both conventional and phosgene-free routes means manufacturers can choose based on regulatory environment, cost, and sustainability goals.

4. High Purity and Broad Supplier Base

As of 2025–2026, approximately 95 global suppliers offer this compound, predominantly Chinese manufacturers. Commercial grades are available at 98–99% purity in quantities from grams to multi-kilogram batches. Key suppliers include Shanghai Bide Pharmatech, Hubei-based chemical companies, and Shandong manufacturers.

5. Growing Downstream Market Drives Demand

Pymetrozine demand continues to grow because:

Resistance management — as neonicotinoid resistance spreads globally, pymetrozine's unique mode of action (stylet blockage) provides a critical rotation option

IPM compatibility — its selectivity toward beneficial insects makes it ideal for integrated pest management programs

Rice intensification — expanding rice production in Asia, Africa, and South America drives herbicide/insecticide demand

Virus transmission control — its ability to block vector-borne plant viruses adds unique value that neurotoxic insecticides cannot match

6. Broader Research Applications

Beyond agrochemicals, the compound is being investigated for:

Antimicrobial agents — inhibiting growth of certain bacteria and fungi

Antiviral drug discovery — potential to inhibit viral replication mechanisms

Anticancer research — triazine scaffolds are explored for cytostatic activity

Fine chemical synthesis — as a reagent for introducing triazine ring systems into complex molecules

7. Favorable Safety and Handling Profile

GHS Classification: GHS07 (Warning) — H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation), H335 (respiratory irritation)

Not classified as acutely toxic or carcinogenic — significantly easier to handle than many agrochemical intermediates

Stable formulation — suitable for long-term storage under standard conditions (cool, dry, sealed)

3-year shelf life — reduces inventory risk for manufacturers and distributors

Summary

Aspect	Detail
Identity	Nitrogen-rich tetrahydro-1,2,4-triazine amide (CAS 136738-23-3)
Primary use	Direct intermediate for pymetrozine insecticide synthesis (Step 4→5→6)
Key selling points	Indispensable pymetrozine precursor; versatile triazine scaffold; multiple scalable routes; 95+ global suppliers; growing downstream demand driven by resistance management and IPM trends
Purity available	98–99% HPLC, gram to multi-kilogram scale
Market context	Pymetrozine is a top-tier rice/cotton/vegetable insecticide with 60%+ market share in Asia

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 4-Acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 4-Acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine.

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