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piperidine-1-carboxylate主图.jpg "China Factory Supply Top Purity sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate CAS 119515-38-7 wholesale")
sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a synthetic, N-protected piperidine derivative used almost exclusively as a specialized building block in medicinal chemistry.
Its structure combines a piperidine ring (a common pharmacophore), a carbamate protecting group on the nitrogen, and a hydroxyethyl side chain. This makes it a versatile intermediate for designing and synthesizing potential drug candidates, particularly for central nervous system targets.
Researchers utilize it to construct complex molecules, studying structure-activity relationships. The protecting group can be removed to reveal a reactive amine, while the alcohol allows for further chemical modifications, enabling efficient exploration of new compounds for pharmacological activity.
Items | Specifications | Results |
Appearance | Clear,colourless to light yellow liquid | Conforms |
Assay | ≥97.0% | 97.8 |
Acetone insolubility | ≤0.3% | 0.05% |
Acidity | ≤0.2% | 0.1 |
Water | ≤0.4% | 0.2 |
Conclusion | The product conforms to the above specifications. | |
sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a specific organic compound belonging to the class of N-protected piperidine derivatives.
Piperidine core: A six-membered saturated heterocycle (containing nitrogen), common in pharmaceuticals.
N-Protection: The nitrogen is protected as a carbamate (specifically, a sec-butyloxycarbonyl, or "Boc-like" group). This makes the amine stable and less reactive during synthetic steps.
Side chain: A 2-hydroxyethyl group is attached to the 2-position of the piperidine ring. This primary alcohol group offers a site for further chemical modification.
Its primary use is as a specialized building block or synthetic intermediate in organic and medicinal chemistry, particularly in pharmaceutical research and development.
Pharmaceutical Intermediate: It is a key precursor in the synthesis of more complex, biologically active molecules. Piperidine scaffolds are prevalent in drugs targeting the central nervous system, as well as in various bioactive alkaloids.
Medicinal Chemistry Probe: Researchers use such well-defined intermediates to systematically modify structures, study structure-activity relationships (SAR), and optimize drug candidates.
Versatile Reactivity: The two functional groups allow for divergent synthesis:
The carbamate can be cleaved under acidic conditions to reveal the secondary amine.
The primary alcohol (hydroxyethyl) can be oxidized, esterified, or used to form other linkages.
This compound is not a common chemical with broad industrial applications. It is a research-grade chemical, likely featured in patent literature or scientific journals as an intermediate in the multistep synthesis of potential drug candidates (e.g., for pain management, neurological disorders, or inflammation).
In summary, sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a sophisticated synthetic intermediate designed for constructing pharmacologically relevant piperidine-based molecules in drug discovery pipelines.
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