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Sodium gentisate is the water-soluble sodium salt of gentisic acid, a natural metabolite of aspirin. It appears as a white crystalline powder.
Its primary and most common use is in veterinary medicine as an injectable analgesic and anti-inflammatory drug for treating pain and fever in large animals like horses and cattle. In human pharmaceuticals, it serves a dual role: as an active ingredient in some anti-arthritic formulations and as an antioxidant stabilizer in injectable solutions. It is also used in biochemical research as a reagent and studied for its antioxidant properties in cosmetic skincare products. The sodium salt form is preferred over the acid for its high solubility, enabling effective liquid and injectable preparations.
Items | Specifications | Results |
Appearance | Pass | |
Water | No more than 18.0% | 15.8% |
Purity | ≥99.0% | 99.7% |
Conclusion | The product conforms to the above specifications. | |
Sodium Gentisate is the sodium salt of gentisic acid (2,5-dihydroxybenzoic acid). It appears as a white to off-white crystalline powder and is highly soluble in water.
Origin: Gentisic acid is a primary metabolite of acetylsalicylic acid (aspirin) in the human body.
Key Traits: It retains some anti-inflammatory and analgesic properties of its parent compound but is often valued for its antioxidant and chelating abilities.
1. Pharmaceutical & Medical
Analgesic & Anti-inflammatory Agent: Used as an active ingredient in some analgesic and anti-arthritic formulations, particularly in certain European and Asian markets. It is sometimes promoted as a better-tolerated alternative for individuals sensitive to aspirin.
Stabilizer & Antioxidant in Formulations: Acts as an antioxidant preservative in injectable solutions and other pharmaceutical preparations.
2. Veterinary Medicine
Large Animal Analgesic: Its most significant and common use is in veterinary medicine, especially for horses, cattle, and dogs. It is administered via intravenous or intramuscular injection to treat musculoskeletal pain, inflammation, and fever.
3. Research & Biochemical Applications
Analytical Reagent: Used in laboratory colorimetric tests and assays.
Precursor in Organic Synthesis: Serves as a starting material or intermediate for synthesizing more complex organic compounds, including potential drugs and dyes.
Model Compound: Studied for its metabolic pathways and antioxidant mechanisms.
4. Cosmetic & Skincare
Antioxidant in Cosmetics: Occasionally incorporated into skincare products for its antioxidant and proposed skin-brightening properties, helping to protect against free radical damage.
The sodium salt form (sodium gentisate) is used instead of the free acid (gentisic acid) primarily for two practical reasons:
Enhanced Solubility: It is much more soluble in water, facilitating the preparation of stable injectable solutions and liquid formulations.
Improved Bioavailability: The salt form generally allows for better and faster absorption in the body.
In summary, Sodium Gentisate is a versatile metabolite of aspirin used chiefly as a veterinary analgesic and anti-inflammatory drug, with additional roles as a pharmaceutical excipient, research chemical, and cosmetic antioxidant.
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