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Rink Amide MBHA Resin is a specialized solid support used in Fmoc solid-phase peptide synthesis (SPPS) to produce C-terminal amidated peptides.
Uses: It is essential for synthesizing bioactive peptides, including complex architectures like cyclic, branched, and stapled peptides, as well as pharmaceuticals like GLP-1 analogs.
Selling Points: It offers superior stability compared to Rink Amide AM resin, making it ideal for peptides with sensitive side chains (Trp, Met, Cys). It allows high-yield, single-step cleavage using 95% TFA. Available in various loadings (0.3–1.0 mmol/g) and mesh sizes, it provides excellent swelling properties for efficient reagent diffusion during long-chain synthesis.
Items | Specifications | Results |
Appearance | light yellow resin pellets | Complies |
Cross-Linking | 1%DVB | |
Bead Size | 100~200mesh | |
Loss on drying | Report | 1.46%(40℃，2h) |
Loading | 0.3-0.8mmol/g | 0.660mmol/g |
Swelling in DCM(ml/g) | Report | 6.99ml/g |
Swelling in DMF(ml/g) | Report | 5.98ml/g |
Conclusion | The product conforms to the above specifications. | |
Product Name:RINK AMIDE MBHA RESIN
CAS:431041-83-7
MF:C47H44N2O6
Melting point :
form:powder
color:White, yellow-white or grayish-white
Uses:
Rink Amide MBHA Resin (CAS No.: 135497-07-3 / 431041-83-7) is a specialized solid-phase support used in Fmoc-based solid-phase peptide synthesis (SPPS). It consists of a modified Rink amide linker attached to MBHA (4-methylbenzhydrylamine) polystyrene resin, crosslinked with 1% DVB. Its primary function is to enable the synthesis of C-terminal amidated peptides, which are the most common bioactive form of peptide drugs.
Key Uses & Applications
C-Terminal Amidated Peptide Synthesis
The resin's Rink amide linker allows direct formation of C-terminal amide structures upon acid cleavage—eliminating the need for additional modification steps. This is critical because most bioactive peptides (e.g., hormones, neuropeptides) require C-terminal amidation for full biological activity.
Complex Peptide Synthesis
Linear peptide amides: Successfully used to synthesize tripeptides, tetrapeptides, pentapeptides, and amphipathic peptides (e.g., [KW]₄, [KW]₅).
Cyclic peptides: Enables on-resin cyclization strategies (head-to-tail or side-chain cyclization via disulfide bonds), producing cyclic peptide amides with enhanced stability and bioactivity.
Branched peptides & stapled peptides: Supports assembly of complex architectures including branched chains and conformationally locked α-helical peptides.
Drug Development
Widely used in pharmaceutical R&D, including the synthesis of GLP-1 analogs (e.g., semaglutide), lanreotide, and other therapeutic peptides. Post-cleavage peptide purity can exceed 80%.
Peptidomimetics & Small Molecules
Also applicable to solid-phase synthesis of non-peptide small molecules containing amide functionalities, such as peptoids and α-helical mimetics.
Property Value
Appearance White to pale yellow microspheres
Particle Size 100–200 mesh (or 200–400 mesh)
Substitution 0.3–1.0 mmol/g
Storage 2–8°C, sealed and dry
Matrix 1% DVB crosslinked polystyrene
Summary
Rink Amide MBHA Resin is a premium solid support for Fmoc-SPPS, particularly valued for synthesizing C-terminal amidated peptides with sensitive side chains. Its enhanced stability, compatibility with complex peptide architectures (cyclic, branched, stapled), and proven track record in drug development (GLP-1 analogs, etc.) make it a preferred choice over standard Rink Amide AM resin for demanding peptide synthesis applications.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Azaperone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Azaperone.
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