Teriparatide acetate can mediate bone metabolism by inhibiting osteoblast apoptosis, activating osteocytic cells, and enhancing osteoblast differentiation.
Teriparatide acetate intermittently stimulates PHT-I receptors on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells by regulating the adenylate cyclase-cyclosyl-cyclosine monophosphate-protein kinase A conduction pathway, promoting the differentiation of osteoblasts and prolonging the life of osteoblasts. Osteoblastic cell line proliferation is stimulated by phosphate C-cytoplasmic calcium-protein kinase C signaling pathway; By inhibiting the transactivation activity of PPARγ, the differentiation of stromal cells into adipocyte lines was reduced, and the number of osteoblasts increased. Indirectly regulates bone growth by regulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation; The process of bone formation is regulated by the Wnt signaling pathway, thereby increasing bone formation.
|Appearance||White to off white powder||Consistent|
|Appearance:||White to off white powder|
|Package details:||10 mg/vial,10 vials/box;1 g/ foil bag|
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