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2-Chloroadenosine CAS 146-77-0 for sale
2-Chloroadenosine CAS 146-77-0 for sale
2-Chloroadenosine CAS 146-77-0 for sale

2-Chloroadenosine CAS 146-77-0 Wholesale & Bulk

2-Chloroadenosine is an important intermediate for cangrelor. 2-Chloroadenosine is an adenosine analogue that is not hydrolyzed by adenosine deaminase. 2-Chloroadenosine increases the rate of dopa production in intact pheochromocytoma cells, it increases the content of cAMP in the cells, and it causes a stable activation of tyrosine hydroxylase, as measured in vitro. The action of 2-Chloroadenosine is not dependent upon extracellular Ca2+. In other experiments, we have found that 2-chloroadenosine increases the activity of adenylate cyclase in membrane fractions prepared from the pheochromocytoma. These data provide support for the hypothesis that 2-Chloroadenosine causes a cAMP-mediated phosphorylation of tyrosine hydroxylase in pheochromocytoma cells. Chromaffin cells and adrenergic neurons store and release adenine nuc1eotides together with catecho1amines. The adenosine formed by the hydrolysis of these nucleotides may be involved in the. physiological regulation of adenylate cyclase activity and of tyrosine hydroxylase activity. To date , however, we have no evidence for such a role of adenosine in normal chromaffin cells or in adrenergic neurons.

Specifications of 2-Chloroadenosine CAS 146-77-0

AppearanceWhite to off-white powderConforms
Assay (HPLC)≥ 98.0%99.08%
Loss on drying≤ 1.0%0.35%

Parameters of 2-Chloroadenosine CAS 146-77-0

Product parameters
Cas number:146-77-0
Appearance:White to off-white powder
Package details:100g/bottle; 1kg/foil bag

Package of our 2-Chloroadenosine CAS 146-77-0 Wholesale

Package of our 2-Chloroadenosine CAS 146-77-0

Application of 2-Chloroadenosine CAS 146-77-0 Bulk

A selective A1-adenosine receptor agonist.

Application of 2-Chloroadenosine CAS 146-77-0

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