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3,5-Diiodo-L-tyrosine dihydrate is a halogenated amino acid intermediate critical for synthesizing thyroid hormones like Levothyroxine (T4) and Liothyronine (T3). Its primary selling point is its indispensable role in manufacturing hypothyroidism treatments, demanding exceptionally high purity (often >98%) to meet strict pharmacopoeia standards. The dihydrate form offers superior stability during storage compared to anhydrous variants, ensuring consistent quality for pharmaceutical production. As the biologically active L-isomer, it guarantees correct stereochemistry for efficient enzymatic coupling in drug synthesis. Beyond manufacturing, it serves as a vital reference standard in clinical diagnostics for thyroid function tests and biochemical research on iodine metabolism. Produced under GMP conditions, it provides the regulatory documentation necessary for global drug approvals. Its specific solubility profile facilitates diverse synthetic pathways, making it a cost-effective, reliable, and compliant choice for laboratories and pharmaceutical companies developing essential endocrine therapies.
Items | Specifications | Results |
Appearance | Light brown powder | Complies |
Purity(HPLC) | ≥98% | 98.91% |
Clarity of solution | 0.01 gram in 2ml 1N NaOH clear solution | Complies |
Loss on drying | ≤4.0%（80℃，2h） | 1.68% |
IR Spectrum | In accordance with the structure | Complies |
Mass Spectrum | In accordance with the structure | Complies |
NMR Spectrum | In accordance with the structure | Complies |
Conclusion | The product conforms to the above specifications. | |
3,5-Diiodo-L-tyrosine dihydrate (CAS No. 18835-59-1; often associated with the anhydrous form CAS 300-39-0) is a halogenated amino acid derivative where two iodine atoms are attached to the phenyl ring of L-tyrosine at the 3 and 5 positions. It exists naturally as an intermediate in the biosynthesis of thyroid hormones within the human body and is a critical building block for pharmaceutical synthesis.
Key Selling Points & Advantages
Critical Pharmaceutical Intermediate:
It is the essential precursor for synthesizing Liothyronine (T3) and Levothyroxine (T4), the primary hormones used to treat hypothyroidism and other thyroid disorders. Its high purity is vital for producing safe and effective end-user medications.
High Purity and Stability:
The dihydrate form offers enhanced stability compared to the anhydrous form, reducing degradation during storage and handling. Commercial grades typically offer purities of 98% to 99%, meeting strict pharmacopoeia standards (USP/EP) required for drug manufacturing.
Biochemical Research Utility:
Widely used in laboratory settings as a standard reference material for studying thyroid metabolism, enzyme kinetics (specifically deiodinases), and radioimmunoassays. It serves as a control in diagnosing thyroid function abnormalities.
Defined Stereochemistry:
As the L-isomer, it possesses the specific stereochemistry required for biological activity and enzymatic coupling reactions, ensuring high yield and correctness in downstream synthetic processes.
Regulatory Compliance:
Produced under Good Manufacturing Practice (GMP) conditions by reputable suppliers, ensuring documentation (COA, MSDS) is available for regulatory submissions in the pharmaceutical industry.
Versatile Solubility Profile:
While sparingly soluble in water, it dissolves readily in dilute alkaline solutions, facilitating its use in various chemical synthesis pathways and analytical preparations.
Typical Applications
Pharmaceutical Manufacturing: Synthesis of thyroid hormone replacement therapies.
Clinical Diagnostics: Calibration and quality control for thyroid function tests.
Life Science Research: Studying iodine metabolism and thyroid hormone signaling pathways.
Note: Due to its role in hormone synthesis, this compound is strictly regulated and typically sold only to licensed pharmaceutical manufacturers, research institutions, and diagnostic laboratories.
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