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Fmoc-Gly-OH is a protected amino acid derivative used as a building block in solid-phase peptide synthesis. It consists of the amino acid Glycine (Gly) with its amine group protected by a Fluorenylmethyloxycarbonyl (Fmoc) group. This protection prevents unwanted reactions during the stepwise assembly of peptides. The carboxylic acid group (-OH) remains reactive, allowing it to form peptide bonds. The Fmoc group is later removed under mild basic conditions, enabling further chain elongation. It is essential for producing synthetic peptides in pharmaceutical and biochemical research.
Items | Specifications | Results |
Appearance | White to off-white powder | White powder |
Purity(HPLC) | ≥99% | 99.71% |
TLC | ≥98% | >98% |
Melting Point | 165-185 ℃ | 175.3-175.7 ℃ |
Clarity of solution | 0.3 gram in 2ml DMF clear solution | Complies |
Water Content(K.F.) | ≤1.0% | 0.19% |
Element analysis(C、H、N) | ≤5.0% | <5.0% |
Loss on drying | ≤1.0%(60 ℃,2h) | 0.10% |
Kaiser Test | <0.05% | <0.05% |
IR Spectrum | In accordance with the structure | Complies |
Mass Spectrum | In accordance with the structure | Complies |
NMR Spectrum | In accordance with the structure | Complies |
Conclusion | It meets the quality inspection standards. | |
Fmoc-Gly-OH is a protected amino acid derivative used primarily in solid-phase peptide synthesis (SPPS). Its name breaks down as follows:
Gly: This is the standard three-letter abbreviation for the amino acid Glycine. It is the simplest amino acid, with a hydrogen atom as its side chain.
Fmoc: Stands for Fluorenylmethyloxycarbonyl. This is a protecting group that blocks the amine group (-NH₂) of the glycine molecule.
-OH: Indicates that the carboxylic acid group (-COOH) of the glycine is free and reactive.
In peptide synthesis, amino acids are linked together by forming a bond between the amine group of one and the carboxylic acid group of another. To prevent unwanted reactions, the amine group must be "protected."
Fmoc-Gly-OH is the building block for incorporating glycine into a growing peptide chain. The Fmoc group protects Glycine's amine functionality during the coupling process. Once the glycine is attached to the chain, the Fmoc group can be easily and selectively removed using a mild base (like piperidine), exposing the amine group so it can react with the next protected amino acid.
Orthogonal Protection: The Fmoc group is stable to acids but easily removed by base. This allows it to be used alongside other acid-labile protecting groups, offering chemists flexibility in synthesizing complex peptides.
Crystallinity: Fmoc-Gly-OH is typically a white, crystalline solid, making it easy to handle, store, and measure accurately in the lab.
Essential Reagent: It is a fundamental and widely used reagent in pharmaceuticals, biochemistry, and research for creating custom peptides and peptide-based drugs.
In summary, Fmoc-Gly-OH is not a drug or a supplement, but a crucial tool for chemists to manually construct peptide molecules, one amino acid at a time.
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