Trabectedin is used in the treatment of inoperable or specific advanced soft tissue sarcomas. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to small grooves in DNA, blocks transcription of stress-induced proteins, induces DNA backbone lysis and apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells.
|Appearance||White or off-white powder||Conforms|
|Appearance:||White or off-white powder|
|Package details:||1g/vial; 10g/PE bottle|
A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata.
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