Tacrolimus is widely used in anti-rejection therapy after various organ transplantations, and is also used in the treatment of autoimmune diseases, kidney diseases, and hematologic diseases.
The immunosuppressive mechanism of tacrolimus is mainly by binding to FK506 receptor-binding protein-12 (FKBP-12) in T lymphocytes to form the Tac-FKBP-12 complex, which binds to calcineurin and inhibits the activation of the latter, interferes with and inhibits the synthesis of interleukin-2 (IL-2) at the molecular level, and inhibits the infiltration of cytotoxic T lymphocytes into grafts, thereby achieving the purpose of preventing and treating rejection.
|Appearance||White to off-white crystalline powder||Conforms|
|Residue on ignition||≤0.1%||0.03%|
|Appearance:||White to off-white crystalline powder|
|Package details:||1g/foil bag|
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