Trimethoprim is used to treat urinary tract infections, intestinal infections, respiratory infections, dysentery, enteritis, typhoid fever, meningitis, otitis media, cerebral flow, sepsis and soft tissue infections. The efficacy of trimethoprim on typhoid and paratyphoid is not lower than that of ampicillin, and can also be combined with long-acting sulfa drugs for the prevention and treatment of drug-resistant falciparum malaria.
The antibacterial spectrum of trimethoprim (TMP) is similar to that of sulfonamides, but the antibacterial effect is strong. It is effective against E. coli, proteus mirabilis, bacillus pneumoniae, staphylococcus saprophyticus, and a variety of gram-positive and negative bacteria.
|Appearance||White or yellowish-white powder||White powder|
|Any single impurity||≤0.1%||＜0.1%|
|Loss on drying||≤1.0%||0.2%|
|Assay||98.5% - 101.0%||99.3%|
|Appearance:||White or yellowish-white powder|
|Purity:||98.5% - 101.0%|
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