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D-Alpha-Tocopheryl Acetate is a natural, fat-soluble form of vitamin E (CAS 58-95-7; C₃₁H₅₂O₃) with strong antioxidant properties. A reddish-brown viscous oil, it is insoluble in water but soluble in organic solvents. Used as a nutritional supplement, food preservative, and pharmaceutical ingredient, it prevents oxidative damage in cells, supports cardiovascular health, and enhances skin protection. Commonly found in cosmetics for anti-aging and in animal feed to improve livestock health. More bioactive than synthetic forms (DL-alpha-tocopheryl acetate), it requires light-protected storage. Safe at recommended doses but excessive intake may cause side effects.
Items | Specifications | Results |
Appearance | Clear, colourless slightly greenish-yellow,Viscous,oily liquid,Ph.Eur./USP/FCC | Clear, colourless slightly greenish-yellow,Viscous,oily liquid |
Identification | Positive | Positive |
Acidity | USP/FCC | ≤1.0ml,USP/FCC |
Residual Solvents | Ph.Eur.2.4.24 USP<467> | To conform(In-house) |
Heavy metals | Pb≤2mg/kg,FCC Arsenic≤1mg/kg(in-house) Copper≤25mg/kg(in-house) Zinc≤25mg/kg(in-house) Palladium≤5ppm(in-house) | <0.5mg/kg <1mg/kg <2mg/kg <2mg/kg <1ppm |
Assay | Ph.Eur.2.2.28(96.5%~102.0%,Ph.Eur.) | 99.0% |
TAMC | USP<61>Ph.Eur.2.6.12(≤1000cfu/g,Ph.Eur./USP) | Certified |
Conclusion | Conform to Ph.Eur./USP/FCC. |
D-Alpha-Tocopheryl Acetate (D-α-Tocopheryl Acetate) is a fat-soluble vitamin E derivative with potent antioxidant properties, widely used in food, pharmaceuticals, cosmetics, and animal feed. Below is a concise overview:
Chemical Name: D-α-Tocopheryl Acetate (Natural Vitamin E)
CAS Number: 58-95-7
Molecular Formula: C₃₁H₅₂O₃
Molecular Weight: 472.74–472.75 g/mol
Appearance: Reddish-brown to red viscous oily liquid or semi-solid at room temperature, with a melting point of ~25–28°C and boiling point of 224°C (0.3 mmHg).
Solubility: Insoluble in water (<0.1 g/100 mL at 17°C), soluble in ethanol, ether, and organic solvents.
Density: 0.953 g/cm³ (25°C).
Refractive Index: 1.494–1.498.
Stability: Sensitive to light and prone to oxidation; requires storage in dark, cool conditions.
Food Industry
Antioxidant: Extends shelf life of oils, margarine, and processed foods by preventing lipid oxidation.
Nutritional Supplement: Fortifies foods to combat vitamin E deficiency.
Pharmaceuticals
Therapeutic Uses: Treats cardiovascular diseases, fatty liver, hypercholesterolemia, infertility, and menopausal symptoms.
Cellular Health: Supports membrane stability and reproductive function.
Cosmetics
Anti-Aging: Reduces UV damage, improves skin elasticity, and delays aging.
Skin Repair: Enhances barrier function and wound healing.
Animal Feed
Health Benefits: Boosts livestock fertility, prevents muscular dystrophy, and supports immune function.
Natural Extraction:
Extracts from plant oil deodorizer distillates (e.g., soybean, palm oil).
Purified via methanol/glycerol extraction or steam distillation.
Synthesis:
Condensation of phytol with trimethylhydroquinone.
Acetylation with acetic anhydride under zinc catalysis.
Steps:
Storage: Keep sealed, away from light and oxidizing agents.
Handling: Use gloves and goggles to avoid skin contact or inhalation.
Toxicity: Non-toxic at recommended doses, but excessive intake may cause diarrhea or metabolic imbalances.
Natural vs. Synthetic: D-α-Tocopheryl Acetate (natural) has 3x higher bioactivity than the synthetic DL-form.
Esterified vs. Free: The acetate ester form is more stable and acts as a prodrug, releasing free tocopherol post-ingestion for sustained antioxidant activity.
Summary: D-Alpha-Tocopheryl Acetate is a vital natural antioxidant with superior bioactivity and stability. Its applications in nutrition, healthcare, and cosmetics highlight its irreplaceable role in protecting cells from oxidative damage and supporting overall health.
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