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DL-Isoleucine (CAS 443-79-8) is the racemic form of the branched-chain amino acid isoleucine, supplied as a white crystalline powder with good water solubility and assay ≥98%. Because only the L-half is bioactive, it is not a substitute for L-isoleucine in sports nutrition; instead it serves as a cost-effective pharmaceutical and peptide-synthesis intermediate, biochemical reagent, culture-media component, and FEMA-listed flavoring agent (FEMA 3295). Produced by chemical synthesis rather than fermentation, it offers a clear price advantage over the L-form while remaining suitable where optical purity is not critical. Its stable, free-flowing solid form, broad compatibility across food-flavor, fine-chemical, and R&D applications, and availability in small research packs make it a practical choice for flavor houses, laboratories, and manufacturers seeking reliable amino-acid raw material.
Specifications of DL-Isoleucine CAS 443-79-8 COA:
Items | Specifications | Results |
Appearance | White crystals or crystalline powder | Conforms |
Assay,% | 98.5~101.5% | 99.1% |
Lead | ≤5mg/kg | <5mg/kg |
Loss on drying | ≤0.3% | 0.16% |
Residue on ignition | ≤0.1% | 0.06% |
Conclusion | The product conforms to the above specifications. | |
CAS:443-79-8
MF:C6H13NO2
Melting point :290 °C (dec.) (lit.)
form:powder
color:White
Uses:
DL-Isoleucine (CAS 443-79-8; also listed as 328-39-2) is the racemic (DL) form of isoleucine, a branched-chain amino acid (BCAA) with molecular formula C₆H₁₃NO₂ and molecular weight 131.17. It is a roughly 1:1 mixture of L-isoleucine (the natural, protein-building, biologically active form) and D-isoleucine (the non-proteinogenic mirror image), and commercial material typically also contains some allo-isoleucine diastereomers.
| Item | Detail |
|---|---|
| Name | DL-Isoleucine / DL-2-amino-3-methylpentanoic acid |
| CAS No. | 443-79-8 |
| FEMA No. | 3295 (flavoring agent) |
| L-form reference | L-Isoleucine CAS 73-32-5 |
| Appearance | White crystalline powder, slightly bitter taste |
| Solubility | Soluble in water (~22 g/L at 25 °C); soluble in hot ethanol/acetic acid; insoluble in ether |
| Melting point | ~290–292 °C (decomposes) |
| Optical rotation | ~0° (racemic) |
| Production | Chemical synthesis (cheaper than fermentation-based L-form) |
Main Uses
1. Pharmaceutical & Peptide Synthesis Intermediate
Chiral building block and starting material for peptide synthesis (solution-phase).
Intermediate in synthesizing antibiotics (e.g., bacitracin-type peptides), peptide drugs, and other bioactive molecules.
Used to introduce specific stereochemistry or as a reference standard in chiral chemistry.
2. Research & Biochemical Reagent
Cell culture media and tissue-culture medium preparation.
Microbial fermentation media component.
Enzyme-specificity studies, D-amino acid oxidase characterization, chiral chromatography standards.
Neuroscience research (D-isoleucine is reported as an Asc-1 antiporter activator).
3. Flavor & Fragrance
Listed as FEMA 3295, used as a flavoring substance in food flavor formulations.
4. Nutritional Fortification (limited, regional)
Used as a nutrient supplement/amino acid fortifier in certain foods and feeds where regulations permit; typical use levels are low (tens of mg/kg). Note that efficacy is lower than L-isoleucine.
5. Animal Feed (with caveats)
Can serve as an isoleucine source in feed, but published data show DL-isoleucine's growth-promoting efficacy is substantially below L-isoleucine (roughly 85% in chicks and 58% in rats), so it is generally not preferred for high-performance livestock/poultry diets.
6. Industrial & Other
Raw material for producing other amino acids and derivatives.
Component in specialty chemical synthesis, surfactants, and agricultural/biocidal chemistries.
Key Selling Points
Cost advantage – Chemically synthesized racemate; typically much cheaper than fermentation-derived L-isoleucine.
Chiral building block – Valuable as a precursor/intermediate where optical purity is resolved later or where chirality isn't critical.
Peptide-synthesis ready – Widely accepted as a reagent-grade material for solution-phase peptide work.
FEMA-listed flavor ingredient – Enables use in flavor systems without needing the full food-grade amino acid dossier.
Research-grade availability – Offered at 98–99% assay with COA/MSDS, small pack sizes, and fast dispatch.
Good water solubility & thermal stability – Easy handling in aqueous media; stable solid up to ~290 °C.
Broad applicability – One SKU serving pharma intermediates, lab reagents, culture media, flavors, and industrial chemistry.
Non-animal / synthetic origin – Suitable for vegan/halal/kosher-positioned supply chains (subject to certification).
Short Marketing Description
DL-Isoleucine (CAS 443-79-8) is a racemic branched-chain amino acid supplied as a white crystalline powder with good water solubility and high assay (≥98%). Primarily used as a pharmaceutical and peptide-synthesis intermediate, biochemical reagent, culture-media component, and FEMA-listed flavoring agent, it offers a cost-effective alternative to L-isoleucine for applications that do not require full biological activity. Its stable, free-flowing form and broad compatibility make it a practical choice for R&D labs, fine-chemical manufacturers, and flavor houses.
For human sports nutrition, clinical nutrition, parenteral/enteral formulas, and high-performance animal feed, specify L-Isoleucine (CAS 73-32-5) instead — only the L-form is efficiently utilized by mammals.
If you intend DL-isoleucine for food/feed use, verify local regulatory status (GB/FDA/EU) and maximum usage levels before claiming nutritional function.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide DL-Isoleucine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of DL-Isoleucine.
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