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-D-Alanine主图.webp "Factory Supply High Quality Best Price (R)-N-Fmoc-(3-Pyridyl)alanine CAS 142994-45-4 with good service wholesale")
Fmoc-3-(3-pyridyl)-D-alanine (CAS 142994-45-4, C₂₃H₂₀N₂O₄, MW 388.42) is an Fmoc-protected, non-proteinogenic D-amino acid—white to off-white powder, soluble in DMF/DMSO, stored sealed at 2–8 °C. Its main use is as a building block in solid-phase peptide synthesis: the D-configuration resists protease cleavage and extends peptide half-life, while the 3-pyridyl side chain contributes hydrogen bonding, π-stacking and metal coordination, tuning polarity, basicity and target binding. It is used in SAR studies, serine-protease inhibitor/probe design, metallo-peptidomimetics, and as an LC-MS reference or impurity standard. Selling points: one residue delivers both anti-enzymatic stability and side-chain tunability; gram-scale, high value density; stable repeat orders from peptide CROs and pharma R&D; quality documented by HPLC ≥98% and ee ≥99% with full CoA/NMR/MS; cross-sell with L-3-Pal, 2-/4-Pal and Boc analogues. Note: irritant, Fmoc is moisture/base-sensitive, RUO only.
Specifications of (R)-N-Fmoc-(3-Pyridyl)alanine CAS 142994-45-4 COA:
Items | Specifications | Results |
Appearance | White to off-white powder | Off-white powder |
Purity(HPLC) | ≥98% | 99.86% |
Optical Purity | ≤0.5%L-enantiomer | 0.01% |
Specific Rotation[α]20/D | +41°~+44°(C=1 in DMF) | +43.0°(C=1 in DMF) |
Melting Point | 155-165℃ | 159.6-161.7℃ |
Clarity of solution | 0.3 gram in 2ml DMF clear solution | Complies |
Water Content(K.F.) | ≤1.0% | 0.11% |
Loss on drying | ≤1.0%(80℃ 2h) | 0.18%(80℃ 2h) |
IR Spectrum | In accordance with the structure | Complies |
Mass Spectrum | In accordance with the structure | Complies |
NMR Spectrum | In accordance with the structure | Complies |
Conclusion | The product conforms to the above specifications. | |
Product Name:Fmoc-3-(3-Pyridyl)-D-Alanine
CAS:142994-45-4
MF:C23H20N2O4
Melting point :159.6-161.7℃
form:powder
color:Off-white
Uses:
Fmoc-3-(3-pyridyl)-D-alanine is a non-proteinogenic (unnatural) amino acid used as a building block in peptide synthesis.
| Item | Details |
|---|---|
| Common names | Fmoc-D-3-Pal-OH; Fmoc-β-(3-pyridyl)-D-Ala-OH |
| CAS | 142994-45-4 (D-form); L-form 175453-07-3 |
| Formula / MW | C₂₃H₂₀N₂O₄ / 388.42 |
| Appearance | White to off-white powder |
| Solubility | Soluble in DMF/DMSO; practically insoluble in water |
| Storage | Sealed, dry, 2–8 °C |
It has three key parts:
Fmoc group: the most common amine protecting group in solid-phase peptide synthesis, removed mildly with piperidine and orthogonal to acid-labile groups.
D-configuration (R): natural amino acids are mostly L-form; switching to D-form makes the bond hard for enzymes to cut, improving peptide stability in vivo.
3-pyridyl side chain: a nitrogen-containing aromatic ring that participates in hydrogen bonding, π-stacking and metal coordination — useful for tuning polarity, basicity and target binding.
2. Main uses
Solid-phase peptide synthesis (SPPS) building block — its primary use; coupled into the chain as a single residue.
Improving peptide stability — the D-configuration resists protease degradation and extends half-life, commonly used in lead optimization.
Structure–activity relationship (SAR) studies — substituting a natural residue with this one to locate key positions.
Protease inhibitor / substrate probe design — the pyridyl side chain fits the S1/S1' pocket of serine proteases such as kallikrein.
Metal coordination & peptidomimetics — pyridine nitrogen coordinates Zn²⁺/Cu²⁺ for metallo-peptide design.
Reference / impurity standard — mg–g scale for LC-MS method development and peptide API impurity profiling.
3. Selling points
Clear function: one residue solves two problems at once — anti-enzymatic cleavage (D-form) plus polarity/basicity tuning (pyridyl).
Small volume, high value: gram-scale packs, high value density, low storage and freight cost.
Stable customer base: peptide CROs, pharma R&D and academic labs; project-driven with strong repeat orders.
Quality easy to prove: HPLC ≥98%, ee ≥99% with chiral/optical rotation report, full CoA/NMR/MS pack → fast customer QC release.
Easy to store and ship: non-volatile solid, refrigerated and light-protected, long shelf life.
Cross-sell friendly: L-3-Pal, 2-Pal, 4-Pal, Boc versions and the free amino acid can be supplied together for library building.
4. Notes
Irritant (H315/H319/H335); wear gloves and eye protection.
Fmoc is moisture- and base-sensitive — keep sealed and cold.
The pyridine nitrogen protonates easily; use HOAt/Oxyma-type additives and short activation to limit racemization.
For research or further manufacturing use only; not for human use, no therapeutic claims.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Fmoc-3-(3-Pyridyl)-D-Alanine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Fmoc-3-(3-Pyridyl)-D-Alanine.
1. Guaranteed purity;
2. Large quantity in stock;
3. Largest manufacturer;
4. Best service after shipment with email;
5. High quality & competitive price;
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