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Glycine tert-butyl ester hydrochloride is a chemically modified, protected form of the simple amino acid glycine. Here, its carboxylic acid group is converted into a tert-butyl ester, and its amino group is stabilized as a hydrochloride salt.
Its core function is as a crucial reagent in organic and peptide chemistry.
Peptide Synthesis: The tert-butyl group acts as a protecting group for the acid, allowing chemists to selectively activate and form peptide bonds at the amino group. This group is easily removed later.
Pharmaceutical Intermediates: It serves as a key starting material for creating more complex molecules, including drugs and fine chemicals that incorporate a glycine unit.
In short, it is a fundamental tool for controlled chemical assembly, especially in producing peptides and active pharmaceutical ingredients (APIs).
Items | Specifications | Results |
Appearance | White crystalline powder | |
Dry weightlessness | ≤1.0% | 0.25 % |
Chloride | 20.0~22.0% | 20.82% |
Melt point | 134℃~144℃ | 136.8℃~140.0℃ |
Content | 98.0%~102.0% | 99.33% |
Purity | ≥98.0% | 98.35% |
Conclusion | The product conforms to the above specifications. | |
Glycine tert-butyl ester hydrochloride is a protected form of the amino acid glycine. It consists of a glycine molecule where the carboxylic acid group is modified into a tert-butyl ester, and the amino group is in its salt form as a hydrochloride.
Its main use is in organic and peptide synthesis as a building block.
Peptide Synthesis: The tert-butyl group acts as a protecting group for the carboxylic acid. This prevents it from reacting while chemists form peptide bonds at the amino group. The protecting group is later removed under mild acidic conditions.
Pharmaceutical Intermediates: It is a key starting material for synthesizing various drugs, peptides, and bioactive compounds that require a glycine unit with a temporarily protected acid function.
In short, it is a reagent used to introduce a glycine unit in a controlled manner during the synthesis of complex molecules, especially peptides and pharmaceuticals.
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