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1-Actamido-3,5-dimethyladmantane is used as an intermediate for memantine.
1-Acetamido-3,5-dimethyladamantane (CAS 19982-07-1) is a specialized organic compound, primarily recognized as Memantine Impurity C. It serves as a critical reference standard in the pharmaceutical industry for quality control of Memantine, a leading Alzheimer’s disease medication.
Its key selling points include:
Regulatory Compliance: Essential for validating purification processes and meeting strict FDA/EMA impurity limits.
Analytical Precision: Used as a high-purity certified reference material for calibrating HPLC systems to ensure drug safety.
Synthetic Utility: Acts as a specific intermediate for researching adamantane derivative structures and optimizing synthesis routes.
Documentation: Reliable suppliers provide full traceability (COA, NMR data), crucial for audit-ready manufacturing environments.
Ultimately, its value lies in enabling the safe, compliant production of neuroprotective therapies rather than direct therapeutic use.
| Items | Specifications | Results |
| Appearance | White solid | Conforms |
| Assay | ≥99% | 99.52% |
| Product parameters | |
| Cas number: | 19982-07-1 |
| Appearance: | White solid |
| Purity: | 99%min |
| Package details: | 1kg/bottle; 25kg/drum |
| Brand: | Fortunachem |
Correct Name: 1-Acetamido-3,5-dimethyladamantane (also known as N-Acetyl Memantine or Memantine Impurity C).
CAS Number: 19982-07-1.
Chemical Formula: C14H23NO
Molecular Weight: ~221.34 g/mol.
Physical Properties: White solid powder; Melting point: 110–111°C; Soluble in methanol and organic solvents.
Primary Identity: It is chemically the N-acetyl derivative of Memantine. Memantine is a widely prescribed medication for treating moderate-to-severe Alzheimer's disease. Consequently, this compound is primarily known in the industry as a key impurity (Impurity C) or a synthetic intermediate in the production of Memantine hydrochloride.
2. Does it have "Selling Points"?
Yes, but its "selling points" are highly specific to the pharmaceutical manufacturing and quality control sectors, not general consumer use. Here are its key market values:
A. Critical Quality Control Standard (The Primary Market)
Regulatory Requirement: Pharmaceutical regulations (FDA, EMA, etc.) require drug manufacturers to identify and quantify impurities in their final products. Since 1-Acetamido-3,5-dimethyladamantane is a known process-related impurity of Memantine, it is essential for:
Calibrating HPLC (High-Performance Liquid Chromatography) equipment.
Validating purification processes.
Ensuring the final Alzheimer's medication meets safety purity standards.
Selling Point: Suppliers sell this as a Certified Reference Material (CRM) or high-purity standard (>98% or >99%) specifically for QC labs. The ability to provide a certificate of analysis (COA) traceable to pharmacopeia standards is the main value driver.
B. Synthetic Intermediate
Process Optimization: It can serve as an intermediate in alternative synthesis routes for Memantine or its analogs. Understanding its formation helps chemists optimize reactions to minimize its presence in the final drug, thereby increasing yield and purity.
Derivatization Research: Researchers may use it to study the structure-activity relationship (SAR) of adamantane derivatives, exploring how the acetyl group affects neuroprotective properties compared to the free amine (Memantine).
C. Niche Supply & Documentation
Specialized Availability: Because it is a specialized chemical, reliable suppliers who can provide small quantities (grams to kilograms) with full documentation (MSDS, COA, structural verification via NMR/MS) hold a competitive advantage.
Stability: As a stable solid, it is easier to handle and store compared to some unstable intermediates, making it a convenient reference standard.
Summary of Differences from Your Previous Query
While 1-Adamantanecarboxylic acid (your previous query) is a building block for creating various adamantane drugs, 1-Acetamido-3,5-dimethyladamantane is specifically tied to the lifecycle of Memantine:
It is what you get if you accidentally acetylate Memantine during synthesis.
It is what you must buy to prove your Memantine drug is pure enough to be sold to patients.
Conclusion: Its "selling point" is not as a standalone drug, but as an indispensable tool for ensuring the safety and regulatory compliance of Alzheimer's medications.
Used as a Memantine intermediate.
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