Name: Chemical Factory Supply High Quality Best Price Ursodeoxycholic Acid CAS 128-13-2 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Ursodeoxycholic Acid CAS 128-13-2

item	specification	result
Appearance	white or Off-white Powder	conform
purity	99%-101%	99.5%

Parameters of Ursodeoxycholic Acid CAS 128-13-2

Product parameters
Cas number:	128-13-2
Appearance:	white or Off-white Powder
Purity:	99.0%-101%
Package details:	25Kg/Drum
Brand:	Fortunachem

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally occurring hydrophilic bile acid found in small amounts in human bile but abundant in bear bile. It is a first-line therapy for various cholestatic liver diseases and gallstone management.

What is Ursodeoxycholic Acid?

Chemical Nature: A secondary bile acid produced by intestinal bacteria from primary bile acids. Unlike most human bile acids which are hydrophobic and potentially toxic to cell membranes, UDCA is highly hydrophilic (water-loving) and non-toxic.

Primary Indications:

Primary Biliary Cholangitis (PBC): The gold-standard treatment to slow disease progression.

Gallstone Dissolution: Specifically for radiolucent (cholesterol) gallstones in patients with functioning gallbladders who cannot undergo surgery.

Cholestasis: Used in pregnancy (intrahepatic cholestasis) and cystic fibrosis-related liver disease.

Emerging Uses: Investigated for neurodegenerative diseases (like ALS) and colorectal cancer prevention due to its cytoprotective properties.

Key Selling Points & Mechanisms

The commercial and clinical value of UDCA lies in its unique multi-target mechanism of action:

Cytoprotection (Cell Shielding):

Displacement of Toxic Bile Acids: UDCA competes with hydrophobic, toxic bile acids (like chenodeoxycholic acid) for absorption and incorporation into cell membranes. By replacing them, it prevents membrane damage and cell death (apoptosis) in liver cells (hepatocytes) and bile duct cells.

Stabilization of Mitochondria: It prevents the opening of the mitochondrial permeability transition pore, a key step in cell death pathways.

Choleretic Effect (Improved Bile Flow):

UDCA stimulates hepatocytes to secrete bile, increasing bile flow. This helps flush out toxic substances and prevents the stagnation of bile (cholestasis) that causes liver damage and itching.

Anti-Inflammatory & Immunomodulatory Effects:

It reduces the expression of aberrant MHC class I molecules on liver cells, making them less visible to the immune system's attack (crucial in autoimmune conditions like PBC).

It inhibits the production of pro-inflammatory cytokines.

Anti-Apoptotic Properties:

UDCA directly inhibits apoptosis (programmed cell death) signaling pathways, preserving liver tissue mass and function.

Safety Profile:

Being a natural substance already present in the body (albeit in small amounts), it has an excellent safety profile with minimal side effects (mostly mild diarrhea), making it suitable for long-term use, even during pregnancy.

Versatility in Formulations:

Available as tablets, capsules, and oral suspensions (the latter being critical for pediatric patients or those with swallowing difficulties, recently highlighted in insurance coverage updates in regions like China for specific indications).

In summary, UDCA is sold as a non-invasive, disease-modifying agent that protects liver cells from toxicity, improves bile flow, and modulates the immune response, making it indispensable for managing chronic cholestatic liver diseases and dissolving cholesterol gallstones.