Temozolomide not only has a good effect on gliomas, but also has obvious therapeutic effects on leukemia, melanoma, lymphoma and solid tumors.
The cytotoxic effect of temozolomide stems from its strong methylation effect on DNA bases. Under alkaline conditions, temozolomide rapidly cleaves to form reactive methyldiazo ions. Because brain tumors are more alkaline than surrounding tissues, the activation of temozolomide can be relatively concentrated in the tumor site, the anti-tumor effect is strong and selective, the side effect spectrum is also improved, the bone marrow toxicity is small, and the tolerability of patients is improved.
|Appearance||Off-white crystalline powder||Conform|
|Loss on drying||≤0.5%||0.35%|
|Assay||98.0% - 102.0%||99.61%|
|Appearance:||Off-white crystalline powder|
|Purity:||98.0% - 102.0%|
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