Neratinib has obvious therapeutic effects on non-small cell lung cancer, colon cancer and breast cancer. Neratinib is a potent and irreversible pan-HER tyrosine kinase inhibitor that works by blocking the signaling pathway transduction of epidermal growth factor receptors HER1, HER2, and HER4; Neratinib has strong selectivity for the ATP binding site of HER2 tyrosine kinase, and reversibly binds to the ATP binding site of the tyrosine kinase region through hydrogen bonding, prevents ATP binding to the tyrosine kinase region, inhibits tyrosine kinase autophosphorylation and activation, thereby inhibiting cell proliferation.
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