Midostaurin is used to treat advanced systemic mastosis. Midostaurin has shown the ability to inhibit FLT3 gene receptor signaling and cell proliferation, induce FLT3 receptor apoptosis in leukemia cells expressing ITD and TKD mutants or overexpressing wild-type FLT3 and plateletderivedgrowth factor (PDGF) receptor cells. Midostaurin also inhibits mast cell KIT signaling, cell proliferation, and histamine release, and induces apoptosis.
|Appearance||White or off-white powder||Conforms|
|Appearance:||White or off-white powder|
|Package details:||1g/vial; 10g/PE bottle|
Used as an antineoplastic agents.
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