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Levonorgestrel is a progestin drug used for menstrual irregularities, functional bleeding of the uterus, endometrial displacement, etc.
Levonorgestrel is a fast-acting, short-term oral contraceptive pill that significantly inhibits ovulation and prevents gestational egg implantation, and increases the consistency of cervical mucus and increases the resistance of sperm penetration, thereby playing a fast-acting contraceptive effect.
Items | Specifications | Results |
Appearance(25℃) | White to almost white crystalline Powder | White crystalline powder |
Identification | IR:Identical to reference standard | Conform |
Melting Point | 232~239℃ Melting range≤4℃ | 232~236℃;4℃ |
Specific Rotation | -30°~-35° | -33° |
Related Substance I | Impurity A≤0.3% | ＜0.05% |
Impurity B≤0.3% | 0.09% | |
Impurity K≤0.3% | ＜0.05% | |
Impurity M≤0.2% | ＜0.05% | |
Impurity S≤0.2% | ＜0.05% | |
Impurity U≤0.2% | N/D | |
Impurity H≤0.15% | ＜0.05% | |
Impurity O≤0.3% | 0.08% | |
Unspecified Impurity≤0.10% | ＜0.05% | |
Total Impurities(Other than O)≤1.0% | 0.09% | |
Related Substance II | ＜0.05% | |
Impurity V≤0.15% | ＜0.05% | |
Residual Solvent | Acetone≤5000 ppm | 759 ppm |
Tetrahydrofuran≤720 ppm | N/D | |
Ethyl Acetate ≤5000 ppm | N/D | |
Methanol≤3000 ppm | N/D | |
Dichloromethane ≤600 ppm | ||
Chloroform ≤60 ppm | N/D | |
Ethynyl group | 7.81%~8.18% | 8.06% |
Loss on Drying | ≤0.5% | 0.04% |
Residue on Ignition | ≤0.1% | 0.02% |
Heavy Metals | ≤20 ppm | ＜20 ppm |
Assay | 98.0%~102.0% | 100.7% |
Partical Size | D90 ≤10μm | 8.12μm |
Storage | Store in cool, dry, enclosed, clean storage areas. Away from strong direct light. | |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 797-63-7 |
| Appearance: | White or almost white crystalline powder |
| Purity: | 98~102% |
| Package details: | 500g or 1kg/bag with foil bag |
| Brand: | Fortunachem |
Uses:
Levonorgestrel: A Comprehensive Overview
Levonorgestrel (also known as D-norgestrel or (−)-norgestrel) is a synthetic progestogen — a man-made version of the natural female hormone progesterone. It is one of the most widely used hormonal agents in the world, found in emergency contraceptive pills, intrauterine devices (IUDs), contraceptive implants, and combined oral contraceptives.
| Property | Details |
|---|---|
| Chemical Name | 13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one |
| CAS Number | 797-63-7 |
| Molecular Formula | C₂₁H₂₈O₂ |
| Molecular Weight | 312.45 g/mol |
| ATC Code | G03AC03 / G03AD01 (WHO) |
Levonorgestrel is the levorotatory (−)-enantiomer of norgestrel, a racemic mixture. Only this enantiomer is hormonally active, with approximately twice the potency of racemic norgestrel. It is classified as a second-generation 19-nortestosterone-derived progestin.
How It Works (Mechanism of Action)
Levonorgestrel prevents pregnancy through several complementary mechanisms, depending on the timing of administration relative to ovulation:
Inhibition or delay of ovulation: Levonorgestrel binds to progesterone receptors in the hypothalamus, suppressing the secretion of gonadotropin-releasing hormone (GnRH). This reduces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, thereby preventing or delaying the LH surge that triggers ovulation. This is its primary mechanism.
Thickening of cervical mucus: Levonorgestrel alters the consistency of cervical mucus, making it thicker and more viscous. This creates a physical barrier that impedes sperm motility and passage through the cervix into the uterus and fallopian tubes, reducing the chance of fertilization.
Endometrial changes: Levonorgestrel can induce morphological changes in the uterine lining (endometrium), such as stromal pseudodecidualization and glandular atrophy, which may reduce the likelihood of implantation of a fertilized egg. However, the clinical relevance of this mechanism — particularly for emergency contraception — remains debated.
Important clarification: Contemporary scientific consensus holds that levonorgestrel's primary contraceptive effect is pre-fertilization. It is not effective once implantation has already begun, and it cannot terminate an existing pregnancy.
Clinical Uses and Formulations
Levonorgestrel is used across a wide range of contraceptive and therapeutic applications:
Emergency Contraception (Morning-After Pill)
Brand names: Plan B One-Step, Next Choice, My Way, Postinor-2, Vikela
Dosage: A single 1.5 mg tablet (or two 0.75 mg tablets taken 12 hours apart)
Timing: Must be taken within 72 hours of unprotected intercourse; efficacy is highest when taken as soon as possible
Effectiveness: Reduces the risk of pregnancy by approximately 79–89% when used as directed; about 7 out of 8 women who would have become pregnant will not
Intrauterine Devices (IUDs)
Brand names: Mirena, Skyla, Liletta, Kyleena
T-shaped devices that release approximately 20 μg/day of levonorgestrel locally into the uterus
Effective for 3–8 years depending on the brand (Mirena up to 8 years)
Over 99% effective at preventing pregnancy
Contraceptive Implants
Brand names: Norplant (discontinued), Jadelle
Subdermal rods implanted under the skin of the upper arm
Provide continuous contraception for up to 5 years
Combined Oral Contraceptives
Used in combination with ethinyl estradiol in pills such as Alesse, Triphasil, and Seasonale
Seasonale is an extended-cycle formulation that reduces menstrual periods to once every 84 days
Hormone Replacement Therapy (HRT)
Combined with estrogen to prevent endometrial hyperplasia and reduce the risk of endometrial cancer associated with unopposed estrogen therapy
Pharmacokinetics
| Parameter | Value |
|---|---|
| Bioavailability | ~100% (oral) |
| Time to Peak (Tmax) | ~1.7 hours |
| Peak Concentration (Cmax) | ~19.1 ng/mL (after 1.5 mg dose) |
| Protein Binding | 97.5–99% (mainly to SHBG and albumin) |
| Volume of Distribution | ~1.8 L/kg |
| Metabolism | Hepatic via CYP3A4 |
| Elimination Half-life | 24–36 hours (range: 20–60 hours) |
| Excretion | ~45% renal, ~32% fecal (primarily as glucuronide conjugates) |
Common Side Effects
Most side effects are mild and self-limiting:
Menstrual changes (heavier, lighter, earlier, or later periods) — most common (~31%)
Nausea (~14%)
Lower abdominal pain (~13%)
Fatigue (~13%)
Headache (~10%)
Dizziness (~10%)
Breast tenderness (~8%)
If vomiting occurs within 2 hours of taking the tablet, a repeat dose may be necessary.
Important Warnings and Considerations
Not an abortifacient: Levonorgestrel will not terminate an existing pregnancy and is contraindicated in known or suspected pregnancy.
No STI protection: It does not protect against HIV/AIDS or any sexually transmitted infections.
Drug interactions: Enzyme-inducing drugs such as phenytoin, carbamazepine, rifampin, barbiturates, and St. John's Wort can reduce levonorgestrel's effectiveness by accelerating its metabolism via CYP3A4.
Body weight considerations: Some research suggests reduced efficacy in women weighing more than 75 kg or with a BMI ≥ 30, though the FDA has not changed labeling based on this evidence.
Ectopic pregnancy risk: Women who experience severe lower abdominal pain 3–5 weeks after taking levonorgestrel should be evaluated for ectopic pregnancy.
Return to fertility: Fertility returns rapidly after discontinuation; routine contraception should be resumed or initiated immediately.
History
Levonorgestrel was first synthesized in the early 1960s by American scientist Herschel Smith at Wyeth Pharmaceuticals. It gained widespread clinical use in the 1980s with the introduction of Norplant (subdermal implant). In 1999, the FDA approved levonorgestrel as a prescription emergency contraceptive (Plan B). In 2006, after extensive debate, Plan B was approved for over-the-counter sale to women aged 18 and older (later extended to all ages without restriction).
In summary, levonorgestrel is a versatile synthetic progestin that works primarily by preventing or delaying ovulation and thickening cervical mucus. It is available in multiple formulations — from single-dose emergency pills to long-acting IUDs and implants — making it one of the most important and widely accessible contraceptive agents in modern medicine.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Levonorgestrel with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Levonorgestrel.
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