Econazole nitrate inhibits the biosynthesis of ergosterol, the main sterol of fungal cell membranes, by interfering with the activity of cytochrome P450, damaging fungal cell membranes and changing their permeability, resulting in leakage of important intracellular substances. Econazole nitrate can inhibit the biosynthesis of triacylglycerol and phospholipids of fungi, inhibit the activity of oxidase and peroxidase, cause intracellular hydrogen peroxide accumulation leading to cell substructure degeneration and cell necrosis.
Econazole nitrate is used in the treatment of tinea pedis, tinea femoralis, tinea corporis, tinea versicolor and cutaneous candidiasis.
|Appearance||White or almost white crystalline powder||White crystalline powder|
|Loss on drying||≤ 0.5%||0.2%|
|Chromatographic purity||≤ 2.0%||<2.0%|
|Sulphated ash||≤ 0.1%||0.01%|
|Appearance:||White or almost white crystalline powder|
|Package details:||25kg/fiber drum|
It is applicable to tinea corporis, tinea manuum, tinea pedis, tinea cruris, tinea corporis, tinea versicolor and cutaneous candidiasis.
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