Chloroquine phosphate has a strong binding force to nuclear proteins, and the negatively charged 7-chloro group on its quinoline ring is close to the 2-amino group on the DNA guanine, allowing chloroquine to be inserted between the two strands of the double helix of DNA. Complexes are formed with DNA, thus preventing DNA replication and RNA transcription. Chloroquine can also inhibit the incorporation of phosphoric acid into the DNA and RNA of the malaria parasite, which interferes with the reproduction of the malaria parasite due to the reduction of nucleic acid synthesis.
Chloroquine phosphate CAS 50-63-5 is a 4-aminoquinoline antimalarial drug, which can inhibit the nucleic acid synthesis of plasmodium schizont, interfere with the growth and reproduction of malaria parasites, and have an efficient killing effect on red endoplasmal schizonts of Plasmodium malaria parasites.
|Appearance||White or almost white crystalline powder||Conform|
|Loss on drying||≤2.0%||0.52%|
|Assay||98.0% - 102.0%||99.6%|
|Appearance:||White or almost white crystalline powder|
|Purity:||98.0% - 102.0%|
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