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Dextran sulfate sodium salt is used as a hypolipidemic and anti-atherosclerotic agent.
Dextran Sulfate Sodium Salt can improve the activity of fibrinolysis system, prevent the deposition and anticoagulation of fibrin, can effectively improve the activity of lipoproteinase, promote esterase free into the blood, decompose chylomicrons, clarify blood lipids, reduce the total cholesterol content in serum, relieve the affinity of β-lipoprotein and fibrin on the blood vessel wall, antagonize the effect of hyaluronidase, and reduce the normal metabolism of the blood vessel wall.
Specifications(COA) of Wholesale Dextran Sulfate Sodium Salt CAS NO 9011-18-1Organic Intermediate
Items | Specifications | Results |
Appearance | White to pale yellow fine powder | Pass |
Identification | Should Conform | Pass |
Solubility (10% solution) | Clear or pale yellow clear solution | Pass |
Moisture | ≤ 10.0% | 4.4% |
pH (10% solution) | 5.5–7.5 | 6.7 |
Total sulfur content | 16.0% – 20.0% | 18.5% |
Free sulfur | ≤ 0.2% | Pass |
Chlorine content | ≤ 0.1% | Pass |
Heavy metals (Lead) | ≤ 8 ppm | Pass |
Conclusion | The product conforms to the above specifications. | |
Basic Information of Dextran Sulfate Sodium Salt | |
Product Name | Dextran Sulfate Sodium Salt |
CAS NO. | 9011-18-1 |
Apperance | White to light yellow powder |
Assay | 98%min |
Pacakge | 1kg/Foil Bag,25kg/Drum/Box |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortunachem |
Uses:
Dextran Sulfate Sodium Salt (DSS)
Dextran Sulfate Sodium Salt (DSS) is a synthetic, polyanionic polysaccharide derived from dextran — a complex glucose polymer — through esterification with chlorosulfonic acid. It exists as the sodium salt form and is typically supplied as a white to off-white, hygroscopic powder that is freely soluble in water, forming a clear, colorless to slightly yellow solution.
Key Chemical Properties
| Property | Detail |
|---|---|
| CAS Number | 9011-18-1 |
| Molecular Formula | (C6H7Na3O14S3)n |
| Molecular Weight Range | 5 kDa – 1,400 kDa (variable) |
| Sulfur Content | ~16–20% (≈1.9–2.3 sulfate groups per glucosyl residue) |
| Appearance | White to off-white powder |
| Solubility | Freely soluble in water (up to 100 mg/mL); slightly soluble in ethanol; insoluble in acetone/ether |
| pH (aqueous) | 4.5–8.0 |
| Structure | α-1,6-glycosidic linked glucose backbone with sulfate groups at C-2, C-3, and C-4 positions, carrying a strong negative charge |
Core Uses & Applications
1. Inflammatory Bowel Disease (IBD) Animal Modeling — The Gold Standard
This is by far the most prominent and widely recognized application of DSS. When administered orally via drinking water (typically 2–5% w/v for 5–7 days), DSS reliably induces colonic inflammation in mice and rats that closely mimics human ulcerative colitis (UC) and Crohn's disease (CD).
How it works:
DSS binds to mucosal epithelial cell surface mucins, disrupting the intestinal barrier
It inhibits epithelial cell proliferation and promotes apoptosis, increasing gut permeability
Gut microbiota and their products (e.g., lipopolysaccharide) translocate into the submucosa
This triggers innate immune cells (macrophages, dendritic cells) via pattern recognition receptors (e.g., Toll-like receptors) to release pro-inflammatory cytokines (IL-6, IL-1β, TNF-α)
Neutrophils and lymphocytes infiltrate, creating a cascade of inflammation
Model types achievable:
Acute colitis — single cycle of DSS drinking water (5–7 days)
Chronic/relapsing colitis — multiple cycles of "DSS water → normal water"
Colitis-associated cancer (CAC) — DSS combined with azoxymethane (AOM)
Optimal molecular weight: 36,000–50,000 Da DSS produces the most stable and reproducible colitis induction.
2. Molecular Biology — Nucleic Acid Hybridization Accelerator
DSS (especially high molecular weight, >500 kDa) is widely used in molecular biology as a molecular crowding agent to accelerate nucleic acid hybridization in techniques such as Southern blot, Northern blot, and fluorescent in situ hybridization (FISH).
At 10% concentration, DSS can increase DNA probe hybridization rates by 10- to 100-fold
It works by occupying solution volume, effectively excluding nucleic acids and raising their effective local concentration
3. Lipoprotein Precipitation & Clinical Chemistry
In the presence of Mg²⁺ ions, DSS selectively precipitates low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) from serum, leaving high-density lipoprotein (HDL) in the supernatant. This is a standard method for HDL cholesterol quantification in clinical diagnostics.
4. Antiviral Research
DSS exhibits antiviral activity by binding to positively charged regions on viral surface proteins, preventing viral adsorption to host cells. It has demonstrated inhibitory effects against:
HIV-1 — blocks viral attachment
Herpes simplex virus
Influenza virus
Lower molecular weight DSS (e.g., 5 kDa) also inhibits complement and coagulation pathways and prevents NK cell-mediated cytotoxicity.
5. Immunology Research
DSS modulates immune responses in several ways:
Polyclonal activation of B lymphocytes (even immature B cells)
Enhancement or suppression of humoral immunity
Modulation of thymocyte reactivity to lectins
Enhancement/suppression of cell-mediated immune responses
Acts as an adjuvant in certain immunization protocols
6. Anticoagulant & Anti-lipemic Agent
DSS has heparin-like activity (~17 international heparin units/mg), acting as an anticoagulant by inhibiting blood coagulation factors and platelet aggregation, and enhancing fibrinolysis. It has been used clinically (under trade names like Aspro and Colyonal) as an antithrombotic and lipid-lowering agent.
7. Drug Delivery & Biomaterials
DSS serves as a polyanionic cross-linker for chitosan, enabling the fabrication of microparticles and nanoparticles for controlled drug delivery systems. It is also used in hydrogel formulations and tissue engineering scaffolds.
8. Cell Culture Additive
In CHO (Chinese Hamster Ovary) cell cultures, DSS has been shown to influence recombinant monoclonal antibody production, affecting cell growth, productivity, and key quality attributes such as aggregation, charge variants, and N-glycosylation profiles.
Key Selling Points
| Selling Point | Explanation |
|---|---|
| Gold-standard IBD model | Globally recognized as the standard tool for inducing experimental colitis; simple oral administration, highly reproducible |
| Wide MW range available | Products span 2 kDa to 1,400 kDa, enabling tailored use across different applications |
| High water solubility | Dissolves readily to form clear solutions, facilitating easy preparation of drinking water solutions or buffer additives |
| Biocompatible & degradable | Low toxicity, naturally degradable with no residual accumulation in vivo |
| Versatile functionality | Single compound serving molecular biology, immunology, virology, clinical chemistry, and drug delivery |
| Well-characterized mechanism | Extensive literature base with clearly elucidated pathways of action |
| High batch-to-batch consistency | Reputable suppliers provide ≥98% purity with defined sulfur content specifications |
| Flexible dosing | Acute, chronic, and relapsing models achievable simply by adjusting concentration and administration schedule |
Summary
Dextran Sulfate Sodium Salt is a remarkably versatile sulfated polysaccharide whose polyanionic character, biocompatibility, and tunable molecular weight make it indispensable across biomedical research. Its single most important application — serving as the gold-standard reagent for inducing experimental colitis in animal models — underpins a vast body of IBD research worldwide. Beyond gastroenterology, its roles in nucleic acid hybridization, lipoprotein separation, antiviral studies, immunology, anticoagulation, and drug delivery further establish it as a high-value, multi-purpose research reagent.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information:
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Dextran Sulfate Sodium Salt with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Dextran Sulfate Sodium Salt.
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2. Large quantity in stock;
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4. Best service after shipment with email;
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